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- W2269577541 abstract "目的比较伴t（8；21）和正常核型的急性髓系白血病（AML）M：患者在诱导缓解后，应用含大剂量阿糖胞苷（HD-Ara-C）方案进行强化巩固治疗的疗效。方法伴t（8；21）（q22；q22）AML．M：患者2l例，正常核型AML—M：患者23例，在诱导缓解后，给予4个疗程HD—Ara-C方案强化治疗：Ara-C3．0g／m^2，每12h1次，静脉滴注持续3h，第1—3天，同时交替联合使用其他药物（米托蒽醌7mg·m^-2·d^-1第1—3天或阿克拉霉素30mg·m^-2·d^-1第1—3天或依托泊甙70mg·m^-2·d^-1第1～3天等）。结果伴t（8；21）患者组复发率29％，3年总体生存（OS）率76％，3年无病生存（DFS）率71％；正常核型组复发率57％，3年OS率65％，3年DFS率43％。两组患者复发率及3年DFS率差异有统计学意义（P〈0．05），3年OS率差异无统计学意义（P〉0．05）。结论伴t（8；21）AML-M2患者诱导缓解后，应用4个疗程含HD-Ara-C方案进行强化巩固治疗，复发率低，可以提高DFS率。" @default.
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- W2269577541 date "2008-01-01" @default.
- W2269577541 modified "2023-09-24" @default.
- W2269577541 title "含大剂量阿糖胞苷方案强化治疗伴t（8；21）和正常核型急性髓系白血病M2患者疗效比较" @default.
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