FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2269804792> ?p ?o ?g. }

• W2269804792 endingPage "283" @default.
• W2269804792 startingPage "273" @default.
• W2269804792 abstract "Background Farm workers in rural areas consume more alcohol than those who reside in urban areas. Occupational exposures such as agricultural work can pose hazards on the respiratory system. It is established that hog barn dust induces inflammation in the airway, including the release of cytokines such as tumor necrosis factor alpha ( TNF ‐α), interleukin‐6 ( IL ‐6), and IL ‐8. We have shown that alcohol alters airway epithelial innate defense through changes in both nitric oxide ( NO ) and cAMP ‐dependent protein kinase A ( PKA ). Simultaneous exposure to hog barn dust and alcohol decreases inflammatory mediators, TNF ‐α, IL ‐6, and IL ‐8, in mice. Previously, mice exposed to both alcohol and hog barn dust showed a depleted amount of lymphocytes compared to mice exposed only to hog barn dust. Weakening of the innate immune response could lead to enhanced susceptibility to disease. In addition, mice that were co‐exposed to hog barn dust and alcohol also experienced increased mortality. Methods Because we recently demonstrated that PKA activation inhibits the TNF ‐α sheddase, TNF ‐α‐converting enzyme ( TACE ), we hypothesized that an alcohol‐mediated PKA pathway blocks TACE activity and prevents the normative inflammatory response to hog barn dust exposure. To delineate these effects, we used PKA pathway inhibitors (adenylyl cyclase [AC], cAMP , and PKA ) to modulate the effects of alcohol on dust‐stimulated TNF ‐α release in the bronchial epithelial cell line, BEAS ‐2B. Alcohol pretreatment blocked TACE activity and TNF ‐α release in hog barn dust‐treated cells. Results Alcohol continued to block hog barn dust‐mediated TNF ‐α release in the presence of the particulate AC inhibitor, SQ 22,536. The soluble adenylyl cyclase inhibitor, KH 7, however, significantly increased the inflammatory response to hog barn dust. phosphodiesterase 4 inhibitors significantly elevated cAMP and enhanced alcohol‐mediated inhibition of dust‐stimulated TNF ‐α release. In addition, the NO synthase inhibitor, l ‐ NMMA , also reversed the alcohol‐blocking effect on dust‐stimulated TNF ‐α. Conclusions These data suggest that alcohol requires a soluble cyclase‐generated cAMP ‐ PKA pathway that is dependent upon the action of NO to inhibit TACE and TNF ‐α release. These findings support our observations that alcohol functions through a dual NO and PKA pathway in bronchial epithelial cells." @default.
• W2269804792 created "2016-06-24" @default.
• W2269804792 creator A5010567062 @default.
• W2269804792 creator A5023653786 @default.
• W2269804792 creator A5030545609 @default.
• W2269804792 creator A5046175017 @default.
• W2269804792 creator A5046186733 @default.
• W2269804792 creator A5069008776 @default.
• W2269804792 creator A5075164788 @default.
• W2269804792 creator A5080599234 @default.
• W2269804792 date "2016-02-01" @default.
• W2269804792 modified "2023-09-27" @default.
• W2269804792 title "Alcohol Decreases Organic Dust-Stimulated Airway Epithelial TNF-Alpha Through a Nitric Oxide and Protein Kinase-Mediated Inhibition of TACE" @default.
• W2269804792 cites W107487080 @default.
• W2269804792 cites W1485195778 @default.
• W2269804792 cites W1577655959 @default.
• W2269804792 cites W1591303624 @default.
• W2269804792 cites W1651344125 @default.
• W2269804792 cites W1982207882 @default.
• W2269804792 cites W1985023878 @default.
• W2269804792 cites W1987601157 @default.
• W2269804792 cites W1992242528 @default.
• W2269804792 cites W1993551530 @default.
• W2269804792 cites W1997204832 @default.
• W2269804792 cites W1999767961 @default.
• W2269804792 cites W2011700930 @default.
• W2269804792 cites W2012595732 @default.
• W2269804792 cites W2017954581 @default.
• W2269804792 cites W2018106241 @default.
• W2269804792 cites W2021423204 @default.
• W2269804792 cites W2026718479 @default.
• W2269804792 cites W2028915128 @default.
• W2269804792 cites W2028918477 @default.
• W2269804792 cites W2029160589 @default.
• W2269804792 cites W2031612481 @default.
• W2269804792 cites W2045283623 @default.
• W2269804792 cites W2054989342 @default.
• W2269804792 cites W2056868795 @default.
• W2269804792 cites W2057302409 @default.
• W2269804792 cites W2062489386 @default.
• W2269804792 cites W2068329623 @default.
• W2269804792 cites W2077086034 @default.
• W2269804792 cites W2079467438 @default.
• W2269804792 cites W2084303426 @default.
• W2269804792 cites W2088120954 @default.
• W2269804792 cites W2094076838 @default.
• W2269804792 cites W2094975370 @default.
• W2269804792 cites W2097838417 @default.
• W2269804792 cites W2102329149 @default.
• W2269804792 cites W2105129720 @default.
• W2269804792 cites W2108195875 @default.
• W2269804792 cites W2113311467 @default.
• W2269804792 cites W2128755985 @default.
• W2269804792 cites W2141677054 @default.
• W2269804792 cites W2144428416 @default.
• W2269804792 cites W2149826057 @default.
• W2269804792 cites W2153337064 @default.
• W2269804792 cites W2160405912 @default.
• W2269804792 cites W2164441020 @default.
• W2269804792 cites W2167363634 @default.
• W2269804792 cites W2214322033 @default.
• W2269804792 cites W2240035390 @default.
• W2269804792 cites W2325259075 @default.
• W2269804792 doi "https://doi.org/10.1111/acer.12967" @default.
• W2269804792 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5656047" @default.
• W2269804792 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26842246" @default.
• W2269804792 hasPublicationYear "2016" @default.
• W2269804792 type Work @default.
• W2269804792 sameAs 2269804792 @default.
• W2269804792 citedByCount "4" @default.
• W2269804792 countsByYear W22698047922017 @default.
• W2269804792 countsByYear W22698047922018 @default.
• W2269804792 countsByYear W22698047922019 @default.
• W2269804792 crossrefType "journal-article" @default.
• W2269804792 hasAuthorship W2269804792A5010567062 @default.
• W2269804792 hasAuthorship W2269804792A5023653786 @default.
• W2269804792 hasAuthorship W2269804792A5030545609 @default.
• W2269804792 hasAuthorship W2269804792A5046175017 @default.
• W2269804792 hasAuthorship W2269804792A5046186733 @default.
• W2269804792 hasAuthorship W2269804792A5069008776 @default.
• W2269804792 hasAuthorship W2269804792A5075164788 @default.
• W2269804792 hasAuthorship W2269804792A5080599234 @default.
• W2269804792 hasBestOaLocation W22698047922 @default.
• W2269804792 hasConcept C126322002 @default.
• W2269804792 hasConcept C134018914 @default.
• W2269804792 hasConcept C136449434 @default.
• W2269804792 hasConcept C17991360 @default.
• W2269804792 hasConcept C184235292 @default.
• W2269804792 hasConcept C185592680 @default.
• W2269804792 hasConcept C203014093 @default.
• W2269804792 hasConcept C2776914184 @default.
• W2269804792 hasConcept C519581460 @default.
• W2269804792 hasConcept C55493867 @default.
• W2269804792 hasConcept C71924100 @default.
• W2269804792 hasConcept C86803240 @default.
• W2269804792 hasConcept C8891405 @default.
• W2269804792 hasConcept C97029542 @default.
• W2269804792 hasConcept C98274493 @default.

• next