Matches in SemOpenAlex for { <https://semopenalex.org/work/W2269844215> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2269844215 endingPage "43" @default.
- W2269844215 startingPage "42" @default.
- W2269844215 abstract "The aqueous-ethanol extract of the Hypericum perforatum (Hp-Ext.) was studied for its possible effect on Naloxone (NLX)-precipitated Opium withdrawal physical signs in rats.Purified Opium was used to induce dependence in rats using 8 days treatment schedule. The animals received Opium extract orally twice daily at 09:00 hrs and 19:00 hrs starting with initial dose of 80 mg/kg (equivalent to 8 mg/kg morphine) and increasing to 650 mg/kg (equivalent to 65 mg/kg morphine). Withdrawal syndrome was precipitated with NLX (0.25 mg/kg, s/c).Animals were divided into three groups each containing nine rats. Group one served as a control and received opium + saline during opium dependence schedule and the remaining two groups were treatment group, one of which received Hp-Ext (20 mg/kg, p/o) one hour before NLX induced withdrawal and was administered opium + saline through out the dependence protocol and 2nd treated group received opium along with Hp-Ext doses though out the dependence protocol. The spasmolytic and calcium antagonist activities of the plant extract were studied using isolated tissue experiments suspended in the Krebs solution maintained at 37 ?C and aerated with carbogen gas.The results showed a significant decrease in both, NLX-induced Opium withdrawal Jumps and Wet Dog Shakes behavior in chronically treated group (ANOVA; P < 0.05 followed by Dunnet post hoc analysis) but no significant effect was found in the acute treatment group. Interestingly, a significant effect was observed on diarrhea in acute treatment group (ANOVA; p < 0.05, followed by Student Newman Keuls test) but no such effect was seen in the chronically treated group. In a separate study, the plant extract inhibited K+-induced contractions in isolated rabbit jejunum and trachea preparations thus showing spasmolytic effect mediated through calcium antagonist activity.In view of the reported fact that NLX-induced opioid withdrawal signs could be inhibited by calcium antagonists, our results indicate the possibility that the opioid withdrawal ameliorating effect of H. perforatum extract may be at least partly though calcium channel blockade.Acknowledgements: We gratefully acknowledge the help and cooperation for the supply of Opium by Anti Narcotic Force (ANF) Peshawar Division. Financial support of University of Pehsawar is also acknowledged." @default.
- W2269844215 created "2016-06-24" @default.
- W2269844215 creator A5020992170 @default.
- W2269844215 creator A5027074508 @default.
- W2269844215 creator A5028465023 @default.
- W2269844215 creator A5038496337 @default.
- W2269844215 creator A5048362914 @default.
- W2269844215 creator A5060535794 @default.
- W2269844215 date "2004-01-01" @default.
- W2269844215 modified "2023-09-27" @default.
- W2269844215 title "EFFECT OF AQUEOUS ETHANOL EXTRACT OF HYPERICUM PERFORATUM ON NALOXANE-PRECIPITATED OPIUM WITHDRAWAL SYNDROME" @default.
- W2269844215 doi "https://doi.org/10.22037/ijpr.2010.418" @default.
- W2269844215 hasPublicationYear "2004" @default.
- W2269844215 type Work @default.
- W2269844215 sameAs 2269844215 @default.
- W2269844215 citedByCount "3" @default.
- W2269844215 countsByYear W22698442152014 @default.
- W2269844215 countsByYear W22698442152019 @default.
- W2269844215 crossrefType "journal-article" @default.
- W2269844215 hasAuthorship W2269844215A5020992170 @default.
- W2269844215 hasAuthorship W2269844215A5027074508 @default.
- W2269844215 hasAuthorship W2269844215A5028465023 @default.
- W2269844215 hasAuthorship W2269844215A5038496337 @default.
- W2269844215 hasAuthorship W2269844215A5048362914 @default.
- W2269844215 hasAuthorship W2269844215A5060535794 @default.
- W2269844215 hasConcept C126322002 @default.
- W2269844215 hasConcept C170493617 @default.
- W2269844215 hasConcept C17744445 @default.
- W2269844215 hasConcept C185592680 @default.
- W2269844215 hasConcept C199539241 @default.
- W2269844215 hasConcept C2776651039 @default.
- W2269844215 hasConcept C2776885963 @default.
- W2269844215 hasConcept C2777170512 @default.
- W2269844215 hasConcept C2777389121 @default.
- W2269844215 hasConcept C2777397205 @default.
- W2269844215 hasConcept C2778195246 @default.
- W2269844215 hasConcept C2778750930 @default.
- W2269844215 hasConcept C2779153319 @default.
- W2269844215 hasConcept C2780852908 @default.
- W2269844215 hasConcept C42219234 @default.
- W2269844215 hasConcept C556039675 @default.
- W2269844215 hasConcept C71924100 @default.
- W2269844215 hasConcept C98274493 @default.
- W2269844215 hasConceptScore W2269844215C126322002 @default.
- W2269844215 hasConceptScore W2269844215C170493617 @default.
- W2269844215 hasConceptScore W2269844215C17744445 @default.
- W2269844215 hasConceptScore W2269844215C185592680 @default.
- W2269844215 hasConceptScore W2269844215C199539241 @default.
- W2269844215 hasConceptScore W2269844215C2776651039 @default.
- W2269844215 hasConceptScore W2269844215C2776885963 @default.
- W2269844215 hasConceptScore W2269844215C2777170512 @default.
- W2269844215 hasConceptScore W2269844215C2777389121 @default.
- W2269844215 hasConceptScore W2269844215C2777397205 @default.
- W2269844215 hasConceptScore W2269844215C2778195246 @default.
- W2269844215 hasConceptScore W2269844215C2778750930 @default.
- W2269844215 hasConceptScore W2269844215C2779153319 @default.
- W2269844215 hasConceptScore W2269844215C2780852908 @default.
- W2269844215 hasConceptScore W2269844215C42219234 @default.
- W2269844215 hasConceptScore W2269844215C556039675 @default.
- W2269844215 hasConceptScore W2269844215C71924100 @default.
- W2269844215 hasConceptScore W2269844215C98274493 @default.
- W2269844215 hasIssue "2" @default.
- W2269844215 hasLocation W22698442151 @default.
- W2269844215 hasOpenAccess W2269844215 @default.
- W2269844215 hasPrimaryLocation W22698442151 @default.
- W2269844215 hasRelatedWork W1572797524 @default.
- W2269844215 hasRelatedWork W2096296582 @default.
- W2269844215 hasRelatedWork W2164543746 @default.
- W2269844215 hasRelatedWork W2185110136 @default.
- W2269844215 hasRelatedWork W2225720887 @default.
- W2269844215 hasRelatedWork W2268329853 @default.
- W2269844215 hasRelatedWork W2268973769 @default.
- W2269844215 hasRelatedWork W2389081611 @default.
- W2269844215 hasRelatedWork W2501744701 @default.
- W2269844215 hasRelatedWork W2528186638 @default.
- W2269844215 hasRelatedWork W2564355364 @default.
- W2269844215 hasRelatedWork W2596013846 @default.
- W2269844215 hasRelatedWork W2621653714 @default.
- W2269844215 hasRelatedWork W2888965488 @default.
- W2269844215 hasRelatedWork W2897416875 @default.
- W2269844215 hasRelatedWork W2903641425 @default.
- W2269844215 hasRelatedWork W3132532728 @default.
- W2269844215 hasRelatedWork W3186212587 @default.
- W2269844215 hasRelatedWork W2052587717 @default.
- W2269844215 hasRelatedWork W2186694985 @default.
- W2269844215 hasVolume "3" @default.
- W2269844215 isParatext "false" @default.
- W2269844215 isRetracted "false" @default.
- W2269844215 magId "2269844215" @default.
- W2269844215 workType "article" @default.