FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2269865867> ?p ?o ?g. }

• W2269865867 endingPage "54" @default.
• W2269865867 startingPage "649" @default.
• W2269865867 abstract "Cell therapy in cardiology is already a reality, as evidenced by the number of ongoing clinical trials. These studies entail administration of either skeletal myoblasts in patients with severe ischemic left ventricular dysfunction or of bone marrow-derived cells in patients with acute myocardial infarction and in whom cell therapy is an adjunct to a percutaneous revascularization procedure. The techniques of preparation, expansion and storage of myoblasts are now quite effective. The problem is simpler for bone marrow cells as in most studies, the procedure is limited to an iliac crest biopsy followed by reinjection of the crude, unfractionated bone marrow, as routinely done in clinical haematology since many years. The results of these studies are not yet fully available. Some of them have been enthusiastically reported to be positive but should be interpreted cautiously because of the usually small sample sizes and the common lack of randomisation and double-blind assessment of outcomes. Thus, the fact that cell therapy has now become a reality should not lead to underscore the yet unsettled fundamental issue, i.e., the ability of this novel mode of therapy to truly regenerate areas of necrotic myocardium and restore function in once akinetic territories. From this standpoint, cell therapy is still a dream. Since the beginning, it has been clear that myoblasts were exclusively committed to differentiate into myotubes, without any evidence for a phenotypic conversion into cardiomyocytes. Although the debate is more controversial for bone marrow cells, the reliance on accurate genetic methods of cell tracking has led to increasingly challenge the purported plasticity of these cells. This by no means implies that cell therapy does not exert beneficial effects that could be mediated by alternate mechanisms like limitation of remodelling of paracrine effects. The basic point is that neither skeletal myoblasts nor bone marrow cells fulfill the major criteria required for a true cardiac regeneration: a coupling of the grafted cells with those of the recipient myocardium and the subsequent generation of a contractile force. It is therefore critical to go on exploring other paths, among which embryonic stem cells are particularly attractive." @default.
• W2269865867 created "2016-06-24" @default.
• W2269865867 creator A5001161346 @default.
• W2269865867 creator A5063067802 @default.
• W2269865867 creator A5071058452 @default.
• W2269865867 date "2005-06-01" @default.
• W2269865867 modified "2023-10-16" @default.
• W2269865867 title "[Myoblast transplantation for heart failure: where are we heading?]." @default.
• W2269865867 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16007819" @default.
• W2269865867 hasPublicationYear "2005" @default.
• W2269865867 type Work @default.
• W2269865867 sameAs 2269865867 @default.
• W2269865867 citedByCount "1" @default.
• W2269865867 crossrefType "journal-article" @default.
• W2269865867 hasAuthorship W2269865867A5001161346 @default.
• W2269865867 hasAuthorship W2269865867A5063067802 @default.
• W2269865867 hasAuthorship W2269865867A5071058452 @default.
• W2269865867 hasConcept C10882517 @default.
• W2269865867 hasConcept C126322002 @default.
• W2269865867 hasConcept C141071460 @default.
• W2269865867 hasConcept C164705383 @default.
• W2269865867 hasConcept C207200792 @default.
• W2269865867 hasConcept C2779079599 @default.
• W2269865867 hasConcept C2780007613 @default.
• W2269865867 hasConcept C28328180 @default.
• W2269865867 hasConcept C2911091166 @default.
• W2269865867 hasConcept C500558357 @default.
• W2269865867 hasConcept C535046627 @default.
• W2269865867 hasConcept C54355233 @default.
• W2269865867 hasConcept C71924100 @default.
• W2269865867 hasConcept C86803240 @default.
• W2269865867 hasConceptScore W2269865867C10882517 @default.
• W2269865867 hasConceptScore W2269865867C126322002 @default.
• W2269865867 hasConceptScore W2269865867C141071460 @default.
• W2269865867 hasConceptScore W2269865867C164705383 @default.
• W2269865867 hasConceptScore W2269865867C207200792 @default.
• W2269865867 hasConceptScore W2269865867C2779079599 @default.
• W2269865867 hasConceptScore W2269865867C2780007613 @default.
• W2269865867 hasConceptScore W2269865867C28328180 @default.
• W2269865867 hasConceptScore W2269865867C2911091166 @default.
• W2269865867 hasConceptScore W2269865867C500558357 @default.
• W2269865867 hasConceptScore W2269865867C535046627 @default.
• W2269865867 hasConceptScore W2269865867C54355233 @default.
• W2269865867 hasConceptScore W2269865867C71924100 @default.
• W2269865867 hasConceptScore W2269865867C86803240 @default.
• W2269865867 hasIssue "6" @default.
• W2269865867 hasLocation W22698658671 @default.
• W2269865867 hasOpenAccess W2269865867 @default.
• W2269865867 hasPrimaryLocation W22698658671 @default.
• W2269865867 hasRelatedWork W2004989845 @default.
• W2269865867 hasRelatedWork W2006018079 @default.
• W2269865867 hasRelatedWork W2131224090 @default.
• W2269865867 hasRelatedWork W2144116495 @default.
• W2269865867 hasRelatedWork W2361188287 @default.
• W2269865867 hasRelatedWork W2366208845 @default.
• W2269865867 hasRelatedWork W2391588020 @default.
• W2269865867 hasRelatedWork W2399063111 @default.
• W2269865867 hasRelatedWork W2443874247 @default.
• W2269865867 hasRelatedWork W3121270373 @default.
• W2269865867 hasVolume "98" @default.
• W2269865867 isParatext "false" @default.
• W2269865867 isRetracted "false" @default.
• W2269865867 magId "2269865867" @default.
• W2269865867 workType "article" @default.