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- W2269867464 abstract "In order to investigate the effect of rectal dissension on the general cardiovascular system, we measured systemic arterial pressure (BP), left ventricular pressure (LVP), +dP/dt, -dP/dt and blood flows to various peripheral tissues (microsphere technique) before and during rectal distension in 35 rats. The rectal distension (intra-rectal pressure increased to 36±12 mmHg by placement of 0.7 ml normal saline into rectal ballon) significantly decreased BP from 134±17 to 114±18 mmHg, LVP (-14%), +dP/dt max (-20%) and –dP/dt max(-20%). These variables returned to control levels by 1.5 to 3.5 min following the end of the 3.5 Min distension period. Rectal distension also produced recurrent ectopic beasts, particularly when extrasystoles were occationally present before the distension. Rectal distension increased anal-rectal blood flow 0.26±0.07 to 0.64±0.14 ml min-1 g-1 (p＜0.05); significantly decreased (p＜0.05) the blood flows to the colon, cecum , ileum, jejunum, stomach, liver, pancreas, kidney and spleen, and had no effect on the blood flows to the esophagus, duodenum, right and left ventricle, brain, diaphragm, thoracic or abdominal skeletal muscles, and abdominal skin. Rectal distension tended to decrease the cardiac output index (COI) form 25±8 to 20±6 ml min-1 100g-1 BW (0.1＞P＞0.05). When the above tissue blood flows were standarsized as a ratio to COI, rectal distension increased the ration to the anal-rectum, but the ratio decreased in spleen and has no effect on the ration of flow to the other gastrointestinal organs, kidneys and peripheral tissues. Therefore, the decreases in the gastro-intestinal and renal blood flows were partially due to the decrease in the cardiac output. These results indicate that rectal distension increases anal—rectal blood flow, but decreased the blood flows to the other gastro-intestinal organs, possibly via cardiac depression. (Tzu-Chi Med j 1994; 6: 245-255)" @default.
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- W2269867464 date "1994-12-01" @default.
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- W2269867464 title "Effect of Rectal Distension on Cardiac Function and Blood Flow Distribution" @default.
- W2269867464 doi "https://doi.org/10.6440/tzucmj.199412.0245" @default.
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