FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2269895946> ?p ?o ?g. }

• W2269895946 endingPage "299" @default.
• W2269895946 startingPage "292" @default.
• W2269895946 abstract "The arthropod-borne West Nile virus (WNV) emerged in New York State in 1999 and quickly spread throughout the United States. Transmission is maintained in an enzootic cycle in which infected mosquitoes transmit the virus to susceptible hosts during probing and feeding. Arthropod-derived components within the viral inoculum are increasingly acknowledged to play a role in infection of vertebrate hosts. We previously showed that Culex tarsalis mosquito saliva and salivary gland extract (SGE) enhance the in vivo replication of WNV. Here, we characterized the effective dose, timing, and proximity of saliva and SGE administration necessary for enhancement of WNV viremia using a mouse model. Mosquito saliva and SGE enhanced viremia in a dose-dependent manner, and a single mosquito bite or as little as 0.01 μg of SGE was effective at enhancing viremia, suggesting a potent active salivary factor. Viremia was enhanced when SGE was injected in the same location as virus inoculation from 24 h before virus inoculation through 12 h after virus inoculation. These results were confirmed with mosquito saliva deposited by uninfected mosquitoes. When salivary treatment and virus inoculation were spatially separated, viremia was not enhanced. In summary, the effects of mosquito saliva and SGE were potent, long lasting, and localized, and these studies have implications for virus transmission in nature, where vertebrate hosts are fed upon by both infected and uninfected mosquitoes over time. Furthermore, our model provides a robust system to identify the salivary factor(s) responsible for enhancement of WNV replication.Mosquito-borne viruses are a significant class of agents causing emerging infectious diseases. WNV has caused over 18,000 cases of neuroinvasive disease in the United States since its emergence. We have shown that Culex tarsalis mosquito saliva and SGE enhance the replication of WNV. We now demonstrate that saliva and SGE have potent, long-lasting, and localized effects. Our model provides a robust system to identify the salivary factor(s) and characterize the mechanism responsible for enhancement of WNV replication. These studies could lead to the identification of novel prophylactic or treatment options useful in limiting the spread of WNV, other mosquito-borne viruses, and the diseases that they cause." @default.
• W2269895946 created "2016-06-24" @default.
• W2269895946 creator A5009466241 @default.
• W2269895946 creator A5026479594 @default.
• W2269895946 creator A5045481974 @default.
• W2269895946 creator A5067548130 @default.
• W2269895946 creator A5084663893 @default.
• W2269895946 date "2016-01-01" @default.
• W2269895946 modified "2023-10-13" @default.
• W2269895946 title "Parameters of Mosquito-Enhanced West Nile Virus Infection" @default.
• W2269895946 cites W1935981180 @default.
• W2269895946 cites W1937155133 @default.
• W2269895946 cites W1963795636 @default.
• W2269895946 cites W1963952857 @default.
• W2269895946 cites W1966396614 @default.
• W2269895946 cites W1969420934 @default.
• W2269895946 cites W1982584351 @default.
• W2269895946 cites W2001359612 @default.
• W2269895946 cites W2006214221 @default.
• W2269895946 cites W2014434275 @default.
• W2269895946 cites W2015380902 @default.
• W2269895946 cites W2015990611 @default.
• W2269895946 cites W2019141994 @default.
• W2269895946 cites W2022286669 @default.
• W2269895946 cites W2025098845 @default.
• W2269895946 cites W2030659751 @default.
• W2269895946 cites W2032814880 @default.
• W2269895946 cites W2034297163 @default.
• W2269895946 cites W2037042953 @default.
• W2269895946 cites W2037744532 @default.
• W2269895946 cites W2042094306 @default.
• W2269895946 cites W2066268626 @default.
• W2269895946 cites W2068185438 @default.
• W2269895946 cites W2068503190 @default.
• W2269895946 cites W2070065041 @default.
• W2269895946 cites W2071138165 @default.
• W2269895946 cites W2081342613 @default.
• W2269895946 cites W2089677648 @default.
• W2269895946 cites W2090862099 @default.
• W2269895946 cites W2094094270 @default.
• W2269895946 cites W2108336788 @default.
• W2269895946 cites W2112835703 @default.
• W2269895946 cites W2114465153 @default.
• W2269895946 cites W2127654242 @default.
• W2269895946 cites W2135290399 @default.
• W2269895946 cites W2136533779 @default.
• W2269895946 cites W2140630012 @default.
• W2269895946 cites W2144967744 @default.
• W2269895946 cites W2144974899 @default.
• W2269895946 cites W2145533822 @default.
• W2269895946 cites W2150299907 @default.
• W2269895946 cites W2160308033 @default.
• W2269895946 cites W2160684102 @default.
• W2269895946 cites W2171529151 @default.
• W2269895946 cites W2176474689 @default.
• W2269895946 cites W2186176009 @default.
• W2269895946 cites W2419616747 @default.
• W2269895946 cites W2421220478 @default.
• W2269895946 doi "https://doi.org/10.1128/jvi.02280-15" @default.
• W2269895946 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4702546" @default.
• W2269895946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26468544" @default.
• W2269895946 hasPublicationYear "2016" @default.
• W2269895946 type Work @default.
• W2269895946 sameAs 2269895946 @default.
• W2269895946 citedByCount "27" @default.
• W2269895946 countsByYear W22698959462016 @default.
• W2269895946 countsByYear W22698959462017 @default.
• W2269895946 countsByYear W22698959462018 @default.
• W2269895946 countsByYear W22698959462019 @default.
• W2269895946 countsByYear W22698959462020 @default.
• W2269895946 countsByYear W22698959462021 @default.
• W2269895946 countsByYear W22698959462022 @default.
• W2269895946 countsByYear W22698959462023 @default.
• W2269895946 crossrefType "journal-article" @default.
• W2269895946 hasAuthorship W2269895946A5009466241 @default.
• W2269895946 hasAuthorship W2269895946A5026479594 @default.
• W2269895946 hasAuthorship W2269895946A5045481974 @default.
• W2269895946 hasAuthorship W2269895946A5067548130 @default.
• W2269895946 hasAuthorship W2269895946A5084663893 @default.
• W2269895946 hasBestOaLocation W22698959461 @default.
• W2269895946 hasConcept C140704245 @default.
• W2269895946 hasConcept C159047783 @default.
• W2269895946 hasConcept C163698547 @default.
• W2269895946 hasConcept C173758957 @default.
• W2269895946 hasConcept C18903297 @default.
• W2269895946 hasConcept C2522874641 @default.
• W2269895946 hasConcept C2776185481 @default.
• W2269895946 hasConcept C2778116200 @default.
• W2269895946 hasConcept C2779518617 @default.
• W2269895946 hasConcept C504460877 @default.
• W2269895946 hasConcept C55493867 @default.
• W2269895946 hasConcept C86803240 @default.
• W2269895946 hasConcept C89423630 @default.
• W2269895946 hasConceptScore W2269895946C140704245 @default.
• W2269895946 hasConceptScore W2269895946C159047783 @default.
• W2269895946 hasConceptScore W2269895946C163698547 @default.
• W2269895946 hasConceptScore W2269895946C173758957 @default.
• W2269895946 hasConceptScore W2269895946C18903297 @default.

• next