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- W2269979065 abstract "G16 can couple indiscriminately to a large number of G protein-coupled receptors (GPCRs), making it a prime candidate as a universal adaptor for GPCRs. In order to increase the promiscuity of Gα16, three chimeras incorporating increasing lengths of Gs-specific residues (25, 44 or 81 residues) into the C-terminus of Gα16 were constructed and named 16s25, 16s44 and 16s81, respectively. The chimeras were examined for their ability to mediate receptor-induced stimulation of phospholipase C (PLC) and Ca2+ mobilization. 16s25 was more effective than 16s44 and 16s81 at coupling to Gs-linked receptors. 16s25 coupled productively to 10 different Gs-coupled receptors examined and, for 50% of these receptors, 16s25-mediated PLC activities were higher than those mediated via Gα16. Similar results were observed for agonist-induced Ca2+ mobilizations. These results show that incorporating the α5 helix of Gαs into Gα16 can increase the promiscuity of 16s25 towards Gs-coupled receptors." @default.
- W2269979065 created "2016-06-24" @default.
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- W2269979065 date "2004-01-01" @default.
- W2269979065 modified "2023-10-01" @default.
- W2269979065 title "Replacement of the α5 helix of Gα16 with Gαs-specific sequences enhances promiscuity of Gα16 toward Gs-coupled receptors" @default.
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- W2269979065 doi "https://doi.org/10.1016/s0898-6568(03)00097-4" @default.
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