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- W2270071163 abstract "We previously found that the combination of an autologous bone mesenchymal stem cell-derived extracellular matrix (aBMSC-dECM) scaffold with bone marrow stimulation could enhance hyaline cartilage regeneration. We suspected that chondrogenic differentiation could be induced by the aBMSC-dECM scaffold. This study aimed to investigate whether aBMSC-dECM scaffolds could promote chondrogenic differentiation without exogenous growth factors. BMSCs were seeded on aBMSC-dECM scaffolds and cultured in vitro with or without transforming growth factor-β3 (E+ or E− group). Atelocollagen scaffolds were used as controls (C+ or C− group). The chondrogenic differentiation was evaluated by histological, biochemical, and real-time polymerase chain reaction assays. After 3 weeks, cartilage-like tissue with a homogeneous structure, a high cartilaginous matrix content (proteoglycan and type II collagen), and high expression levels of cartilage-associated genes (COL2A1, ACAN, and SOX9) were observed in the E+, E−, and C+ groups. In addition, BMSCs in each scaffold (E group or C group) were preconditioned with chondrogenic media in vitro for 1 week, and then implanted in the backs of nude mice for 3 weeks. Three weeks later, cartilage matrix formation (proteoglycan and type II collagen) was achieved only in the E group, confirmed by safranin O staining and immunohistochemical staining for type II collagen. Taken together, these results indicate that aBMSC-dECM scaffolds could induce chondrogenic differentiation. Thus, they could be successful candidate scaffolds for cartilage tissue engineering." @default.
- W2270071163 created "2016-06-24" @default.
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- W2270071163 date "2016-02-01" @default.
- W2270071163 modified "2023-09-27" @default.
- W2270071163 title "Chondrogenic Differentiation Could Be Induced by Autologous Bone Marrow Mesenchymal Stem Cell–Derived Extracellular Matrix Scaffolds Without Exogenous Growth Factor" @default.
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- W2270071163 doi "https://doi.org/10.1089/ten.tea.2014.0491" @default.
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