FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2270243929> ?p ?o ?g. }

• W2270243929 endingPage "G608" @default.
• W2270243929 startingPage "G599" @default.
• W2270243929 abstract "Our previous studies showed that Lactobacillus acidophilus (LA) culture supernatant (CS) increased P-glycoprotein [Pgp/multidrug resistance 1 (MDR1)] function, expression, and promoter activity in Caco-2 cells. The current studies were designed to elucidate the molecular mechanisms mediating the stimulatory effects of LA CS on Pgp promoter activity. Deletion analysis indicated that the LA CS response element(s) is located in the −172/+428-bp region, and sequence analysis of this region revealed three potential binding sites for c-Fos or c-Jun: proximal activating protein (AP) 1a (−119/−98 bp), distal AP1b (−99/−78 bp), and AP1c (+175/+196 bp). LA CS (24 h) showed an approximately twofold increase in the protein expression of c-Fos and c-Jun in Caco-2 cells. Electrophoretic mobility shift assay showed that LA CS markedly increased the binding of Caco-2 nuclear proteins to AP1a and AP1b, but not AP1c. The DNA-protein complex was completely eliminated by c-Fos antibody, while c-Jun antibody partially eliminated the complex. Chromatin immunoprecipitation analysis also showed that LA CS enhanced the association of c-Fos and c-Jun (by ∼4- and 1.5-fold, respectively) with endogenous Pgp promoter in Caco-2 cells (p−172/+1). Interestingly, overexpression of c-Fos or c-Jun activated Pgp promoter by nearly twofold each. This increase was further enhanced (∼14-fold) when c-Fos and c-Jun were simultaneously overexpressed, suggesting that the presence of one of these transcription factors potentiates the effect of the other. These studies, for the first time, provide evidence for the involvement of c-Fos/c-Jun in stimulation of Pgp gene expression by LA CS in the human intestine." @default.
• W2270243929 created "2016-06-24" @default.
• W2270243929 creator A5002264441 @default.
• W2270243929 creator A5016617625 @default.
• W2270243929 creator A5045604140 @default.
• W2270243929 creator A5056585454 @default.
• W2270243929 creator A5056923271 @default.
• W2270243929 creator A5067027209 @default.
• W2270243929 creator A5077583166 @default.
• W2270243929 creator A5088621768 @default.
• W2270243929 date "2016-04-15" @default.
• W2270243929 modified "2023-10-18" @default.
• W2270243929 title "<i>Lactobacillus acidophilus</i>stimulates intestinal P-glycoprotein expression via a c-Fos/c-Jun-dependent mechanism in intestinal epithelial cells" @default.
• W2270243929 cites W1498554246 @default.
• W2270243929 cites W1551725906 @default.
• W2270243929 cites W1964115760 @default.
• W2270243929 cites W1966243693 @default.
• W2270243929 cites W1970746718 @default.
• W2270243929 cites W1974424681 @default.
• W2270243929 cites W1980851434 @default.
• W2270243929 cites W2005532504 @default.
• W2270243929 cites W2009145554 @default.
• W2270243929 cites W2010193336 @default.
• W2270243929 cites W2019018134 @default.
• W2270243929 cites W2026097288 @default.
• W2270243929 cites W2026828260 @default.
• W2270243929 cites W2029073712 @default.
• W2270243929 cites W2031272027 @default.
• W2270243929 cites W2034460839 @default.
• W2270243929 cites W2040821545 @default.
• W2270243929 cites W2041633812 @default.
• W2270243929 cites W2043348459 @default.
• W2270243929 cites W2050341344 @default.
• W2270243929 cites W2054049548 @default.
• W2270243929 cites W2056010853 @default.
• W2270243929 cites W2066372209 @default.
• W2270243929 cites W2073395843 @default.
• W2270243929 cites W2081004372 @default.
• W2270243929 cites W2081864509 @default.
• W2270243929 cites W2084348113 @default.
• W2270243929 cites W2089739167 @default.
• W2270243929 cites W2090910729 @default.
• W2270243929 cites W2102267843 @default.
• W2270243929 cites W2110934836 @default.
• W2270243929 cites W2114330559 @default.
• W2270243929 cites W2128566951 @default.
• W2270243929 cites W2129364961 @default.
• W2270243929 cites W2129637436 @default.
• W2270243929 cites W2131026799 @default.
• W2270243929 cites W2131766686 @default.
• W2270243929 cites W2139387284 @default.
• W2270243929 cites W2139759128 @default.
• W2270243929 cites W2141878383 @default.
• W2270243929 cites W2146127468 @default.
• W2270243929 cites W2148963522 @default.
• W2270243929 cites W2149809125 @default.
• W2270243929 cites W2149934511 @default.
• W2270243929 cites W2152575922 @default.
• W2270243929 cites W2153551892 @default.
• W2270243929 cites W2154276474 @default.
• W2270243929 cites W2154863999 @default.
• W2270243929 cites W2158032510 @default.
• W2270243929 cites W2163542601 @default.
• W2270243929 cites W2163636362 @default.
• W2270243929 cites W3172331528 @default.
• W2270243929 doi "https://doi.org/10.1152/ajpgi.00210.2015" @default.
• W2270243929 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4836133" @default.
• W2270243929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26867563" @default.
• W2270243929 hasPublicationYear "2016" @default.
• W2270243929 type Work @default.
• W2270243929 sameAs 2270243929 @default.
• W2270243929 citedByCount "15" @default.
• W2270243929 countsByYear W22702439292017 @default.
• W2270243929 countsByYear W22702439292018 @default.
• W2270243929 countsByYear W22702439292019 @default.
• W2270243929 countsByYear W22702439292020 @default.
• W2270243929 countsByYear W22702439292021 @default.
• W2270243929 countsByYear W22702439292022 @default.
• W2270243929 crossrefType "journal-article" @default.
• W2270243929 hasAuthorship W2270243929A5002264441 @default.
• W2270243929 hasAuthorship W2270243929A5016617625 @default.
• W2270243929 hasAuthorship W2270243929A5045604140 @default.
• W2270243929 hasAuthorship W2270243929A5056585454 @default.
• W2270243929 hasAuthorship W2270243929A5056923271 @default.
• W2270243929 hasAuthorship W2270243929A5067027209 @default.
• W2270243929 hasAuthorship W2270243929A5077583166 @default.
• W2270243929 hasAuthorship W2270243929A5088621768 @default.
• W2270243929 hasBestOaLocation W22702439291 @default.
• W2270243929 hasConcept C101762097 @default.
• W2270243929 hasConcept C104317684 @default.
• W2270243929 hasConcept C134320426 @default.
• W2270243929 hasConcept C138885662 @default.
• W2270243929 hasConcept C150194340 @default.
• W2270243929 hasConcept C153911025 @default.
• W2270243929 hasConcept C159654299 @default.
• W2270243929 hasConcept C179926584 @default.
• W2270243929 hasConcept C183978625 @default.
• W2270243929 hasConcept C185592680 @default.

• next