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- W2270296717 abstract "Histology is fundamental to assess two-dimensional intestinal inflammation; however, inflammatory bowel diseases (IBDs) are often indistinguishable microscopically on the basis of mucosal biopsies. Here, we use stereomicroscopy (SM) to rapidly profile the entire intestinal topography and assess inflammation. We examine the mucosal surface of >700 mice (encompassing >16 strains and various IBD-models), create a profiling catalogue of 3D-stereomicroscopic abnormalities and demonstrate that mice with comparable histological scores display unique sub-clusters of 3D-structure-patterns of IBD pathology, which we call 3D-stereoenterotypes, and which are otherwise indiscernible histologically. We show that two ileal IBD-stereoenterotypes ('cobblestones' versus 'villous mini-aggregation') cluster separately within two distinct mouse lines of spontaneous ileitis, suggesting that host genetics drive unique and divergent inflammatory 3D-structural patterns in the gut. In humans, stereomicroscopy reveals 'liquefaction' lesions and hierarchical fistulous complexes, enriched with clostridia/segmented filamentous bacteria, running under healthy mucosa in Crohn's disease. We suggest that stereomicroscopic (3D-SMAPgut) profiling can be easily implemented and enable the comprehensive study of inflammatory 3D structures, genetics and flora in IBD." @default.
- W2270296717 created "2016-06-24" @default.
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- W2270296717 creator A5070485730 @default.
- W2270296717 date "2015-07-08" @default.
- W2270296717 modified "2023-10-11" @default.
- W2270296717 title "Stereomicroscopic 3D-pattern profiling of murine and human intestinal inflammation reveals unique structural phenotypes" @default.
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- W2270296717 cites W1971517634 @default.
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- W2270296717 cites W1990984319 @default.
- W2270296717 cites W2002535233 @default.
- W2270296717 cites W2004751481 @default.
- W2270296717 cites W2007584793 @default.
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- W2270296717 cites W2037259539 @default.
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- W2270296717 cites W2042048278 @default.
- W2270296717 cites W2047947935 @default.
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- W2270296717 cites W2071067542 @default.
- W2270296717 cites W2073878909 @default.
- W2270296717 cites W2076821480 @default.
- W2270296717 cites W2083793985 @default.
- W2270296717 cites W2084072475 @default.
- W2270296717 cites W2093090644 @default.
- W2270296717 cites W2099376946 @default.
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- W2270296717 cites W2141597037 @default.
- W2270296717 cites W2142231009 @default.
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- W2270296717 cites W2148220041 @default.
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- W2270296717 doi "https://doi.org/10.1038/ncomms8577" @default.
- W2270296717 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4510646" @default.
- W2270296717 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26154811" @default.
- W2270296717 hasPublicationYear "2015" @default.
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