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- W2270302893 abstract "1975 Objectives Patients with aluminum hydroxide-induced MMF mainly complain of arthromyalgias, chronic fatigue and cognitive deficits. Routine brain MRI is usually not contributive. This study aimed to characterize brain perfusion abnormalities in these patients. Methods Brain perfusion SPECT was performed in 76 consecutive patients (aged 49±9 y) followed in the Reference Center for Neuromuscular Diseases Garches-Necker-Mondor-Hendaye. Images were acquired 30 min after intravenous injection of 925 MBq 99mTc-ECD at rest. All patients also underwent a comprehensive battery of neuropsychological tests exploring up to 35 cognitive domains, within 1.3±5.5 mo from brain SPECT. Statistical parametric maps (SPM2) were obtained for each cognitive domain after dividing the patients in 2 groups depending on their performance on tests ( to the median of z-scores) using an ANCOVA design with 3 nuisance variables (age, delay SPECT-tests, socio-cultural level). Results Patients were characterized by a neuropsychological profile of dysexecutive syndrome, with impairment in attention, processing speed, working memory, executive functions and visuospatial organization domains, while language and verbal memory domains were preserved. SPM analysis revealed areas of hypoperfusion correlated with the respective cognitive deficits: for example, trail making (TMTA/B) and Zazzo cancellation tests correlated with hypoperfusions in posterior associative areas, free/cued recall tests correlated with hippocampus hypoperfusions, Rey-Ostereith recall correlated with cerebellar and frontal hypoperfusions, Brown-Peterson distractor tasks correlated with dorso-frontal hypoperfusions. Conclusions Brain perfusion SPECT shows diffuse cortical and subcortical abnormalities, correlated with the predominantly dysexecutive syndrome characterizing aluminum hydroxide-induced MMF patients" @default.
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- W2270302893 date "2012-05-01" @default.
- W2270302893 modified "2023-10-03" @default.
- W2270302893 title "Brain perfusion SPECT correlate of cognitive deficits in patients with aluminum hydroxide-induced macrophagic myofasciitis (MMF)" @default.
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