Matches in SemOpenAlex for { <https://semopenalex.org/work/W2270432829> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2270432829 endingPage "1086" @default.
- W2270432829 startingPage "1086" @default.
- W2270432829 abstract "1086 Objectives According to recent reports, the dimeric RGD peptide tracer showed higher receptor-binding affinity and specificity for integrin αvβ3 in vitro and enhanced tumor uptake and retention in vivo as compared with the monomeric RGD peptide[1, 2]. Based on above studies, we designed a noble dimeric cyclic RGD labeled radioactive Cu-64 for an effective tumor imaging, which was prepared with two cyclic RGDfK, bifunctional chelator (BFCA) and glucosamine. Glucosamine was used for the purpose of increasing the blood clearance and reducing the liver uptake[3]. Methods The derivatives of glyco-BFCA-di-c(RGDfK) was prepared as three types of NODAGA, NOTA and DOTA. After labeling Cu-64 with analogues of glyco-BFCA-di-c(RGDfK), they were conducted the serum stability test for 24h, respectively. Imaging studies and Biodistribution were used the nude mouse bearing U87MG glioma cancer cell. The organ uptake (10μCi) in U87MG-bearing mice was calculated as a percentage of the injected dose per gram of organ tissue (%ID/g). PET imaging of each dimeric RGD peptide was obtained at 1h, 2.5h, 4h, and 16h as tumor-bearing mice administered with 230μCi into the tail vein. Results The serum stability test of glyco-BFCA-di-c(RGDfK) derivatives was very stable as radiochemical purity of over 95% by ITLC. Biodistribution results of each derivatives were showed higher tumor uptake after 1h as follows : 3.89 ± 0.56 (glyco-NODAGA-di-c(RGDfK)), 3.99 ± 0.98(glyco-DOTA-di-c(RGDfK)), 3.81 ± 0.58(glyco-NOTA-di-c(RGDfK)). In addition, PET imaging of above derivatives was showed the most high uptake of tumor at 1h in mice bearing tumor and was obtained for 40h. Conclusions We introduced Cu-64 labeled glyco-BFCA-di-c(RGDfK) combines easy accessibility with high serum stability and good imaging properties making it an interesting alternative to the monomeric RGD peptide as PET radiopharmaceutical for tumor imaging. Research Support This research was supported from a National Research Foundation of Korea (NRF) grant funded by the Korean government (MEST) (2012-0006388)." @default.
- W2270432829 created "2016-06-24" @default.
- W2270432829 creator A5001112321 @default.
- W2270432829 creator A5009204601 @default.
- W2270432829 creator A5013563942 @default.
- W2270432829 creator A5020191539 @default.
- W2270432829 creator A5033256758 @default.
- W2270432829 creator A5037387803 @default.
- W2270432829 creator A5047013777 @default.
- W2270432829 creator A5067781865 @default.
- W2270432829 creator A5074289440 @default.
- W2270432829 creator A5084091866 @default.
- W2270432829 date "2013-05-01" @default.
- W2270432829 modified "2023-09-27" @default.
- W2270432829 title "Synthesis and biological evaluation of dimeric RGD peptide conjugated Cu-64 and glucosamine for tumor imaging" @default.
- W2270432829 hasPublicationYear "2013" @default.
- W2270432829 type Work @default.
- W2270432829 sameAs 2270432829 @default.
- W2270432829 citedByCount "0" @default.
- W2270432829 crossrefType "journal-article" @default.
- W2270432829 hasAuthorship W2270432829A5001112321 @default.
- W2270432829 hasAuthorship W2270432829A5009204601 @default.
- W2270432829 hasAuthorship W2270432829A5013563942 @default.
- W2270432829 hasAuthorship W2270432829A5020191539 @default.
- W2270432829 hasAuthorship W2270432829A5033256758 @default.
- W2270432829 hasAuthorship W2270432829A5037387803 @default.
- W2270432829 hasAuthorship W2270432829A5047013777 @default.
- W2270432829 hasAuthorship W2270432829A5067781865 @default.
- W2270432829 hasAuthorship W2270432829A5074289440 @default.
- W2270432829 hasAuthorship W2270432829A5084091866 @default.
- W2270432829 hasConcept C112613896 @default.
- W2270432829 hasConcept C150903083 @default.
- W2270432829 hasConcept C177322064 @default.
- W2270432829 hasConcept C178790620 @default.
- W2270432829 hasConcept C185592680 @default.
- W2270432829 hasConcept C197404232 @default.
- W2270432829 hasConcept C202751555 @default.
- W2270432829 hasConcept C207001950 @default.
- W2270432829 hasConcept C2777807558 @default.
- W2270432829 hasConcept C2778125326 @default.
- W2270432829 hasConcept C2778172261 @default.
- W2270432829 hasConcept C2779281246 @default.
- W2270432829 hasConcept C2779931791 @default.
- W2270432829 hasConcept C521977710 @default.
- W2270432829 hasConcept C55493867 @default.
- W2270432829 hasConcept C71240020 @default.
- W2270432829 hasConcept C86803240 @default.
- W2270432829 hasConceptScore W2270432829C112613896 @default.
- W2270432829 hasConceptScore W2270432829C150903083 @default.
- W2270432829 hasConceptScore W2270432829C177322064 @default.
- W2270432829 hasConceptScore W2270432829C178790620 @default.
- W2270432829 hasConceptScore W2270432829C185592680 @default.
- W2270432829 hasConceptScore W2270432829C197404232 @default.
- W2270432829 hasConceptScore W2270432829C202751555 @default.
- W2270432829 hasConceptScore W2270432829C207001950 @default.
- W2270432829 hasConceptScore W2270432829C2777807558 @default.
- W2270432829 hasConceptScore W2270432829C2778125326 @default.
- W2270432829 hasConceptScore W2270432829C2778172261 @default.
- W2270432829 hasConceptScore W2270432829C2779281246 @default.
- W2270432829 hasConceptScore W2270432829C2779931791 @default.
- W2270432829 hasConceptScore W2270432829C521977710 @default.
- W2270432829 hasConceptScore W2270432829C55493867 @default.
- W2270432829 hasConceptScore W2270432829C71240020 @default.
- W2270432829 hasConceptScore W2270432829C86803240 @default.
- W2270432829 hasLocation W22704328291 @default.
- W2270432829 hasOpenAccess W2270432829 @default.
- W2270432829 hasPrimaryLocation W22704328291 @default.
- W2270432829 hasRelatedWork W1968173729 @default.
- W2270432829 hasRelatedWork W1990506324 @default.
- W2270432829 hasRelatedWork W2008766422 @default.
- W2270432829 hasRelatedWork W2016535122 @default.
- W2270432829 hasRelatedWork W2022709099 @default.
- W2270432829 hasRelatedWork W2044808829 @default.
- W2270432829 hasRelatedWork W2046200653 @default.
- W2270432829 hasRelatedWork W2055421103 @default.
- W2270432829 hasRelatedWork W2065246138 @default.
- W2270432829 hasRelatedWork W2087694021 @default.
- W2270432829 hasRelatedWork W2094348788 @default.
- W2270432829 hasRelatedWork W2121620801 @default.
- W2270432829 hasRelatedWork W2141306685 @default.
- W2270432829 hasRelatedWork W2150746548 @default.
- W2270432829 hasRelatedWork W2187193321 @default.
- W2270432829 hasRelatedWork W2387068852 @default.
- W2270432829 hasRelatedWork W2468140111 @default.
- W2270432829 hasRelatedWork W2585698517 @default.
- W2270432829 hasRelatedWork W3207404993 @default.
- W2270432829 hasRelatedWork W382588605 @default.
- W2270432829 hasVolume "54" @default.
- W2270432829 isParatext "false" @default.
- W2270432829 isRetracted "false" @default.
- W2270432829 magId "2270432829" @default.
- W2270432829 workType "article" @default.