Matches in SemOpenAlex for { <https://semopenalex.org/work/W2270442270> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2270442270 abstract "Introduction Study107 is an open-label rollover study of telaprevir (T) with peginterferon+ ribavirin (PR) in genotype-1 HCV patients who did not achieve SVR following PR treatment in telaprevir Phase 2 studies. Method Null responders ( 10 HCV RNA decrease at week-4 or 10 at week-12), partial responders (=2-log 10 decrease at week 12, detectable at week 24), patients with viral breakthrough and relapsers from PROVE1/2/3 PR arms were eligible for treatment. Initially all patients received T 750 mg q8h plus PR at standard doses for 12 weeks, followed by 12 weeks of PR (T12/PR24). Protocol was amended to allow partial responders, viral breakthroughs and relapsers with undetectable HCV RNA at weeks 4 and 12 (eRVR) to receive T12/PR24. Partial responders, viral breakthroughs and relapsers with detectable HCV RNA at week 4 and/or week 12 and null responders received an additional 24 weeks of PR (T12/PR48). Results Of 117 patients included in an ITT analysis, 97 (83%) had baseline HCV RNA=800 000 IU/ml, (69) 59% had genotype subtype 1a, 44 (38%) had cirrhosis or bridging fibrosis, and 9 (8%) were black. Viral breakthrough and relapse rates occurred in 25%, 23% of prior null responders; 10%, 22% of prior partial responders; 13%, 0% of prior viral breakthroughs; and 0%, 4% of prior relapsers. Conclusion Patients with prior relapse, breakthrough and partial response exhibited high SVR rates after 24 weeks of telaprevir-based regimen. High SVR rates were also observed in patients with previous null response after 48 weeks of therapy." @default.
- W2270442270 created "2016-06-24" @default.
- W2270442270 creator A5009203630 @default.
- W2270442270 creator A5013964835 @default.
- W2270442270 creator A5024023232 @default.
- W2270442270 creator A5038426997 @default.
- W2270442270 creator A5040817770 @default.
- W2270442270 creator A5041319315 @default.
- W2270442270 creator A5045504446 @default.
- W2270442270 creator A5051725247 @default.
- W2270442270 creator A5064179616 @default.
- W2270442270 creator A5073197069 @default.
- W2270442270 creator A5073253611 @default.
- W2270442270 creator A5082309779 @default.
- W2270442270 date "2010-09-01" @default.
- W2270442270 modified "2023-09-24" @default.
- W2270442270 title "P66 SVR with telaprevir, peginterferon alfa-2A and ribavirin in HCV patients with well-characterised prior null response, partial response, viral breakthrough or relapse after peginterferon+ ribavirin" @default.
- W2270442270 doi "https://doi.org/10.1136/gut.2010.223362.92" @default.
- W2270442270 hasPublicationYear "2010" @default.
- W2270442270 type Work @default.
- W2270442270 sameAs 2270442270 @default.
- W2270442270 citedByCount "0" @default.
- W2270442270 crossrefType "journal-article" @default.
- W2270442270 hasAuthorship W2270442270A5009203630 @default.
- W2270442270 hasAuthorship W2270442270A5013964835 @default.
- W2270442270 hasAuthorship W2270442270A5024023232 @default.
- W2270442270 hasAuthorship W2270442270A5038426997 @default.
- W2270442270 hasAuthorship W2270442270A5040817770 @default.
- W2270442270 hasAuthorship W2270442270A5041319315 @default.
- W2270442270 hasAuthorship W2270442270A5045504446 @default.
- W2270442270 hasAuthorship W2270442270A5051725247 @default.
- W2270442270 hasAuthorship W2270442270A5064179616 @default.
- W2270442270 hasAuthorship W2270442270A5073197069 @default.
- W2270442270 hasAuthorship W2270442270A5073253611 @default.
- W2270442270 hasAuthorship W2270442270A5082309779 @default.
- W2270442270 hasConcept C126322002 @default.
- W2270442270 hasConcept C142462285 @default.
- W2270442270 hasConcept C203014093 @default.
- W2270442270 hasConcept C2522874641 @default.
- W2270442270 hasConcept C2776235749 @default.
- W2270442270 hasConcept C2776408679 @default.
- W2270442270 hasConcept C2776455275 @default.
- W2270442270 hasConcept C2777214474 @default.
- W2270442270 hasConcept C2778159067 @default.
- W2270442270 hasConcept C2780040827 @default.
- W2270442270 hasConcept C2781413609 @default.
- W2270442270 hasConcept C71924100 @default.
- W2270442270 hasConcept C90924648 @default.
- W2270442270 hasConceptScore W2270442270C126322002 @default.
- W2270442270 hasConceptScore W2270442270C142462285 @default.
- W2270442270 hasConceptScore W2270442270C203014093 @default.
- W2270442270 hasConceptScore W2270442270C2522874641 @default.
- W2270442270 hasConceptScore W2270442270C2776235749 @default.
- W2270442270 hasConceptScore W2270442270C2776408679 @default.
- W2270442270 hasConceptScore W2270442270C2776455275 @default.
- W2270442270 hasConceptScore W2270442270C2777214474 @default.
- W2270442270 hasConceptScore W2270442270C2778159067 @default.
- W2270442270 hasConceptScore W2270442270C2780040827 @default.
- W2270442270 hasConceptScore W2270442270C2781413609 @default.
- W2270442270 hasConceptScore W2270442270C71924100 @default.
- W2270442270 hasConceptScore W2270442270C90924648 @default.
- W2270442270 hasLocation W22704422701 @default.
- W2270442270 hasOpenAccess W2270442270 @default.
- W2270442270 hasPrimaryLocation W22704422701 @default.
- W2270442270 hasRelatedWork W1959884270 @default.
- W2270442270 hasRelatedWork W1968947132 @default.
- W2270442270 hasRelatedWork W1978061638 @default.
- W2270442270 hasRelatedWork W1988983163 @default.
- W2270442270 hasRelatedWork W2008050329 @default.
- W2270442270 hasRelatedWork W2024049300 @default.
- W2270442270 hasRelatedWork W2057755792 @default.
- W2270442270 hasRelatedWork W2060691408 @default.
- W2270442270 hasRelatedWork W2063470257 @default.
- W2270442270 hasRelatedWork W2072969050 @default.
- W2270442270 hasRelatedWork W2085317708 @default.
- W2270442270 hasRelatedWork W2093112028 @default.
- W2270442270 hasRelatedWork W2094890430 @default.
- W2270442270 hasRelatedWork W2123653775 @default.
- W2270442270 hasRelatedWork W2143374555 @default.
- W2270442270 hasRelatedWork W2156112450 @default.
- W2270442270 hasRelatedWork W2169082093 @default.
- W2270442270 hasRelatedWork W2316282668 @default.
- W2270442270 hasRelatedWork W3140658322 @default.
- W2270442270 hasRelatedWork W3147276859 @default.
- W2270442270 hasVolume "59" @default.
- W2270442270 isParatext "false" @default.
- W2270442270 isRetracted "false" @default.
- W2270442270 magId "2270442270" @default.
- W2270442270 workType "article" @default.