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- W2270442712 abstract "ABSTRACT Aim: MicroRNAs (miRs) are non-coding RNAs that regulate gene expression of several genes involved in cancer. Because their stability, these small molecules are potential to be blood-based markers for cancer diagnosis, staging, prognosis and response to treatment. The aim of this work was to analyze the prognostic and predictive role of circulating miRs as potential biomarkers of metastatic castration-resistant prostate cancer (mCRPC). Methods: Peripheral blood from 87 mCRPC patients was collected. Fifty of them were obtained previously to chemotherapy treatment. The expression of 10 miRs selected from the literature as previously related to PC progression (miR21, miR34a, miR141, miR143, miR145, miR146a, miR205, miR221, miR222 and let7c) was analyzed at the mononuclear cells population by quantitative reverse transcriptase-polymerase chain reaction. Forty-three samples were analyzed in parallel for circulant tumor cells (CTC) count (CellSearch®). MiRs expression data were correlated with clinical characteristics, outcome, taxanes response and CTC count. Results: MiR143 and miR34a were significantly overexpressed in patients with ≥ 5 CTCs (n = 20) in comparison with those with Conclusions: This study suggests the utility of peripheral blood miRs detection as potential prognostic biomarker for mCRPC. Moreover, its association with chemotherapy response suggests a potential predictive value that needs to be further validated. Disclosure: All authors have declared no conflicts of interest." @default.
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- W2270442712 date "2014-09-01" @default.
- W2270442712 modified "2023-10-14" @default.
- W2270442712 title "Micrornas Expression in Blood Associated with Taxanes Response and Overall Survival in Metastatic Castration-Resistant Prostate Cancer" @default.
- W2270442712 doi "https://doi.org/10.1093/annonc/mdu336.27" @default.
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