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W2270484789 startingPage "155" @default.
W2270484789 abstract "Despite a billion years of divergent evolution, the baker's yeast Saccharomyces cerevisiae has long proven to be an invaluable model organism for studying human biology. Given its tractability and ease of genetic manipulation, along with extensive genetic conservation with humans, it is perhaps no surprise that researchers have been able to expand its utility by expressing human proteins in yeast, or by humanizing specific yeast amino acids, proteins or even entire pathways. These methods are increasingly being scaled in throughput, further enabling the detailed investigation of human biology and disease-specific variations of human genes in a simplified model organism." @default.
W2270484789 created "2016-06-24" @default.
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W2270484789 creator A5073382053 @default.
W2270484789 creator A5079751395 @default.
W2270484789 date "2015-10-13" @default.
W2270484789 modified "2023-10-06" @default.
W2270484789 title "Efforts to make and apply humanized yeast" @default.
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W2270484789 doi "https://doi.org/10.1093/bfgp/elv041" @default.
W2270484789 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4803062" @default.
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