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• W2270505513 abstract "O uso de estatinas previamente à intervenção coronária percutânea (ICP) tem reduzido eventos cardíacos na evolução de curto e longo prazos. Avaliamos o impacto do uso prévio de estatinas nos resultados hospitalares da ICP em pacientes com síndrome coronariana aguda (SCA). Métodos: Análise retrospectiva de registro multicêntrico com 6.288 pacientes submetidos consecutivamente à ICP. Destes, 35% tinham SCA e foram avaliados de acordo com a utilização (Grupo 1, n = 1.203) ou não (Grupo 2, n = 999) de estatinas. O Grupo 1 mostrou maior prevalência de dislipidemia, infarto agudo do miocárdio (IAM) prévio, procedimentos de revascularização prévios, insuficiência renal crônica, acometimento multiarterial, lesões em bifurcação uso de stents farmacológicos. O Grupo 2 mostrou maior número de ICPs primária e de resgate, classe funcional Killip III/IV, lesões tipo B2/C, trombos, oclusões totais, fluxo TIMI pré 0/1, presença de circulação colateral, uso de inibidores da glicoproteína IIb/IIIa e de cateteres de aspiração. O sucesso da ICP foi maior no Grupo 1 (95,1% vs. 92,5%; p = 0,01), e a ocorrência de eventos cardíacos e cerebrovasculares adversos maiores (ECCAM) (3,7% vs. 5,7%; p = 0,04) foi mais frequente no Grupo 2. Apesar da não utilização de estatina ter apresentado associação com ECCAM na análise univariada, foram preditores independentes de ECCAM hospitalares apenas o IAM em Killip III/IV e a cirurgia de revascularização prévia. Pacientes com SCA submetidos à ICP e que estavam em uso prévio de estatinas apresentaram melhores resultados clínicos hospitalares, mas a utilização desses fármacos não foi preditora independente de ECCAM. The use of statins prior to percutaneous coronary intervention (PCI) has reduced cardiac events in both short and long‐term follow‐up. This study assessed the impact of prior statin use on in‐hospital PCI outcomes in patients with acute coronary syndrome (ACS). Retrospective analysis of a multicenter registry of 6,288 consecutive patients undergoing PCI. Of these, 35% had ACS and were evaluated according to statin use (Group 1, n = 1,203) or no use (Group 2, n = 999). Group 1 showed higher prevalence of dyslipidemia, acute myocardial infarction (AMI), previous coronary artery bypass graft, chronic renal failure, multivessel involvement, bifurcation lesions, and use of drug‐eluting stents. Group 2 showed more primary and rescue PCIs, Killip functional class III/IV, B2/C lesions, thrombi, total occlusions, pre‐procedural TIMI 0/1 flow, presence of collateral circulation, and use of glycoprotein IIb/IIIa inhibitors and aspiration catheters. PCI success was higher in Group 1 (95.1% vs. 92.5%; p = 0.01), and the occurrence of major adverse cerebrovascular and cardiac events (MACCE) (3.7% vs. 5.7%) was more frequent in Group 2. Although the non‐use of statins showed an association with MACCE in the univariate analysis, independent predictors of in‐hospital MACCE were limited to AMI in Killip III/IV and prior coronary artery bypass graft. ACS patients undergoing PCI who previously used statins had better in‐hospital clinical outcomes; however, statin use was not an independent predictor of MACCE." @default.
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• W2270505513 date "2015-04-01" @default.
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• W2270505513 title "Impacto do uso prévio de estatinas nos resultados da intervenção coronária percutânea na síndrome coronariana aguda" @default.
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