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• W2270525504 abstract "We have recently shown that a linear current-to-voltage (I-V) relationship of membrane conductance (passive conductance) reflects the intrinsic property of K+ channels in mature astrocytes. While passive conductance is known to underpin a highly negative and stable membrane potential (VM) essential for the basic homeostatic function of astrocytes, a complete repertoire of the involved K+ channels remains elusive. TREK-1 two-pore domain K+ channel (K2P) is highly expressed in astrocytes, and covalent association of TREK-1 with TWIK-1, another highly expressed astrocytic K2P, has been reported as a mechanism underlying the trafficking of this heterodimer channel to the membrane and contributing to astrocytes’ passive conductance. To decipher the individual contribution of TREK-1 and address whether the appearance of passive conductance is conditional to the co-expression of TWIK-1/TREK-1 in astrocytes, TREK-1 single and TWIK-1/TREK-1 double gene knockout mice were used in the present study. The relative quantity of mRNA encoding other astrocyte K+ channels, such as Kir4.1, Kir5.1, and TREK-2, was not altered in these gene knockout mice. Whole-cell recording from hippocampal astrocytes in situ revealed no detectable changes in astrocyte passive conductance, VM, or membrane input resistance (Rin) in either kind of gene knockout mouse. Additionally, TREK-1 proteins were mainly located in the intracellular compartments of the hippocampus. Altogether, genetic deletion of TREK-1 alone or together with TWIK-1 produced no obvious alteration in the basic electrophysiological properties of hippocampal astrocytes. Thus, future research focusing on other K+ channels may shed light on this long-standing and important question in astrocyte physiology." @default.
• W2270525504 created "2016-06-24" @default.
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• W2270525504 date "2016-02-03" @default.
• W2270525504 modified "2023-10-16" @default.
• W2270525504 title "Genetic Deletion of TREK-1 or TWIK-1/TREK-1 Potassium Channels does not Alter the Basic Electrophysiological Properties of Mature Hippocampal Astrocytes In Situ" @default.
• W2270525504 cites W108909600 @default.
• W2270525504 cites W125443444 @default.
• W2270525504 cites W1482320560 @default.
• W2270525504 cites W1541419413 @default.
• W2270525504 cites W1864765563 @default.
• W2270525504 cites W1967902520 @default.
• W2270525504 cites W1968001136 @default.
• W2270525504 cites W1973192586 @default.
• W2270525504 cites W1976372374 @default.
• W2270525504 cites W1980908115 @default.
• W2270525504 cites W1981893433 @default.
• W2270525504 cites W1997674536 @default.
• W2270525504 cites W2009771635 @default.
• W2270525504 cites W2015720543 @default.
• W2270525504 cites W2034361715 @default.
• W2270525504 cites W2037279364 @default.
• W2270525504 cites W204348490 @default.
• W2270525504 cites W2044329917 @default.
• W2270525504 cites W2050706464 @default.
• W2270525504 cites W2062279581 @default.
• W2270525504 cites W2063063986 @default.
• W2270525504 cites W2063632792 @default.
• W2270525504 cites W2067094678 @default.
• W2270525504 cites W2068200390 @default.
• W2270525504 cites W2072019664 @default.
• W2270525504 cites W2073363721 @default.
• W2270525504 cites W2078923024 @default.
• W2270525504 cites W2081895884 @default.
• W2270525504 cites W2081996944 @default.
• W2270525504 cites W2082355313 @default.
• W2270525504 cites W2083818620 @default.
• W2270525504 cites W2083971880 @default.
• W2270525504 cites W2084388603 @default.
• W2270525504 cites W2091520623 @default.
• W2270525504 cites W2093156360 @default.
• W2270525504 cites W2095931805 @default.
• W2270525504 cites W2099448643 @default.
• W2270525504 cites W2101174197 @default.
• W2270525504 cites W2110921852 @default.
• W2270525504 cites W2116616972 @default.
• W2270525504 cites W2117088742 @default.
• W2270525504 cites W2119690334 @default.
• W2270525504 cites W2120878067 @default.
• W2270525504 cites W2124940469 @default.
• W2270525504 cites W2127621191 @default.
• W2270525504 cites W2129082075 @default.
• W2270525504 cites W2129567809 @default.
• W2270525504 cites W2130061890 @default.
• W2270525504 cites W2130213507 @default.
• W2270525504 cites W2131597783 @default.
• W2270525504 cites W2135730315 @default.
• W2270525504 cites W2142439573 @default.
• W2270525504 cites W2143070723 @default.
• W2270525504 cites W2144437938 @default.
• W2270525504 cites W2146582067 @default.
• W2270525504 cites W2148981717 @default.
• W2270525504 cites W2155479383 @default.
• W2270525504 cites W2157194890 @default.
• W2270525504 cites W2162338856 @default.
• W2270525504 cites W2163061108 @default.
• W2270525504 cites W2163755116 @default.
• W2270525504 cites W2167368466 @default.
• W2270525504 cites W2168580744 @default.
• W2270525504 cites W2227238226 @default.
• W2270525504 cites W2278495047 @default.
• W2270525504 cites W2311237560 @default.
• W2270525504 cites W2340486640 @default.
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• W2270525504 doi "https://doi.org/10.3389/fncel.2016.00013" @default.
• W2270525504 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4738265" @default.
• W2270525504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26869883" @default.
• W2270525504 hasPublicationYear "2016" @default.
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