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- W227063998 abstract "[Objective]To detect the protective effect of salvianolte on the focal cerebral ischemia-reperfusion injury in rats and to reveal the mechanism. [Methods] 48 SD rats were divided into four group randomly, sham control group, ischemia control group, salvianolate (10 mg/kg) group and salvianolate (30 mg/kg) group, each group contain 6 rats. We used the Longa method to establish the MCAO model. The salvianolte at different dose were injected introperitoneally at the different time point according to the test design. The cerebral infarction volume by TTC stain and behavior scores by Longa's methods were also determined in order to evaluated the protective effect. Also we used assay kit to determine the activities of SOD and GSH-Px, content of MDA in each group. [Results] (1) Compared with ischemia control group, salvianolate could obviously reduce behavior scores and cerebral infarction volume, and the results were more obvious in salvianolate (30 mg/kg) group than in salvianolate (10 mg/kg) group. (2) The activities of SOD and GSH-Px of serum in the ischemia control group, salvianolate (10 mg/kg) group and salvianolate (30 mg/kg) group were much lower than those in normal control group. But the salvianotes can inhibit this decrease. (3) The content of MDA of brain tissue in the ischemia control group, salvianolate (10 mg/kg) group and salvianolate (30 mg/kg) group were much higher than those in normal control group. The salvianolate can inhibit this increase. [Conclusion] Salvianolate plays neuroprotective effect maybe through modulating the imbalance of oxidant and antioxidant inducing by the cerebral ischemia-reperfusion." @default.
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- W227063998 date "2009-01-01" @default.
- W227063998 modified "2023-09-22" @default.
- W227063998 title "The effect of salvianolate on the focal cerebral ischemia-reperfusion injury in rats." @default.
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