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• W2270660001 abstract "2086 Background: To analyze retrospectively the risk factors of spinal recurrence in patients with intracranial germinoma and clinical outcomes of patients who developed spinal recurrence. Methods: From 1980 to 2007, 165 patients with no evidence of spinal metastases at diagnosis were treated with cranial radiotherapy without spinal irradiation. One hundred three patients (62%) were treated using a radiation field encompassing the whole brain with or without a boost, 43 patients with the whole ventricle with or without a boost, and 19 patients with a localized-field smaller than the whole ventricle. The total dose to the primary site ranged from 24 to 59.5 Gy (median: 48.5 Gy). Seventy-five patients (45%) received systemic chemotherapy during the initial treatment and the median follow-up in all 165 patients was 61.2 months (range, 1.2–260.1 months). Results: After the initial treatment, 15 patients (9.1%) developed spinal recurrences. Multivariate analysis revealed that intracranial large (> 4 cm) disease and intracranial multiple/disseminated disease were independent risk factors for spinal recurrence. Radiation field, total radiation dose and the use of chemotherapy did not affect the occurrence of spinal recurrence. Concerning 15 patients who experienced spinal recurrence, the 3-year actuarial overall survival and disease-free survival (DFS) rates from the beginning of salvage treatments were 65% and 57%, respectively. In the analysis, presence of intracranial recurrence and salvage treatment modality (radiotherapy with chemotherapy vs. radiotherapy alone) had a statistically significant impact on DFS. The 3-year DFS rate in patients with no intracranial recurrence and treated with both spinal radiotherapy and chemotherapy was 100%, while only 17% in patients with intracranial recurrence and/or treated with radiotherapy alone (p = 0.001). Conclusions: When treating patients with intracranial germionma with no evidence of spinal metastases at diagnosis, craniospinal irradiation appears to be appropriate for patients with intracranial large disease and intracranial multiple/disseminated disease. For patients with spinal recurrence alone, salvage treatment combined with spinal radiotherapy and chemotherapy could control the recurrent disease. No significant financial relationships to disclose." @default.
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• W2270660001 date "2008-05-20" @default.
• W2270660001 modified "2023-10-07" @default.
• W2270660001 title "Risk factors and treatment outcomes of spinal recurrence from intracranial germinoma" @default.
• W2270660001 doi "https://doi.org/10.1200/jco.2008.26.15_suppl.2086" @default.
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