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• W2270793869 abstract "Background . Taurine transporter gene expression (RNA-TauT) has a role in retinal cell function and is modulated in vitro and in vivo by hyperglycemia and/or oxidative stress. This study was aimed at testing whether RNA-TauT gene expression is modified in blood mononuclear peripheral cells (MPCs) of type 1 diabetic patients, is related to plasma markers of oxidative stress or endothelial dysfunction, or, finally, is related to presence of retinopathy. Methods . RNA-TauT was measured in MPCs by real-time PCR-analysis in 35 type 1 diabetic patients and in 33 age- and sex-matched controls, additionally measuring plasma and cell taurine and markers of oxidative stress and endothelial dysfunction. Results . RNA-TauT, expressed as<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:msup><mml:mrow><mml:mn mathvariant=normal>2</mml:mn></mml:mrow><mml:mrow><mml:mo>-</mml:mo><mml:mi mathvariant=normal>Δ</mml:mi><mml:mi mathvariant=normal>Δ</mml:mi><mml:mi mathvariant=normal>C</mml:mi><mml:mi mathvariant=normal>t</mml:mi></mml:mrow></mml:msup></mml:mrow></mml:math>, was significantly higher in MPCs of type 1 diabetic patients than in controls [median (interquartile range): 1.32(0.31) versus 1.00(0.15);<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>0.01</mml:mn></mml:math>]. In diabetic patients RNA-TauT was related to HbA1c (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mi>r</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>0.42</mml:mn></mml:math>;<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>0.01</mml:mn></mml:math>) and inversely to plasma homocysteine (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mi>r</mml:mi><mml:mo>=</mml:mo><mml:mo>-</mml:mo><mml:mn fontstyle=italic>0.39</mml:mn></mml:math>;<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>0.02</mml:mn></mml:math>) being additionally significantly higher in MPCs of patients without retinopathy [(<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M7><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>22</mml:mn></mml:math>); 1.36(0.34)] compared to those with retinopathy [(<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M8><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>13</mml:mn></mml:math>); 1.16(0.20)], independently from HbA1c or diabetes duration. Conclusions . RNA-TauT gene expression is significantly upregulated in MPCs of type 1 diabetes patients and is related to HbA1c levels and inversely to plasma homocysteine. Finally, in diabetes patients, RNA-TauT upregulation seems to be blunted in patients with retinopathy independently of their metabolic control or longer diabetes duration." @default.
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• W2270793869 date "2016-01-01" @default.
• W2270793869 modified "2023-10-12" @default.
• W2270793869 title "Taurine Transporter Gene Expression in Mononuclear Blood Cells of Type 1 Diabetes Patients" @default.
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• W2270793869 doi "https://doi.org/10.1155/2016/7313162" @default.
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