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• W2270892604 abstract "Intravascular ultrasound imaging of the pulmonary arteries has been demonstrated to be a reliable method of quantifying vessel diameter, luminal area and pulsatility. Simultaneous measurement of flow velocity and its response to vasodilators allows the relationship between morphology and functional compromise to be studied, especially endothelial dysfunction. In 51 patients (mean age=49·8±12·6 years, 17 female) we performed right heart catheterization and simultaneous intravascular ultrasound of pulmonary artery branches. The patients were divided in two groups: group 1 with normal pulmonary artery pressure and pulmonary vascular resistance, and group 2 with pulmonary hypertension (peak pulmonary artery pressure >30 mmHg and/or mean pulmonary artery pressure >20 mmHg). Vessel wall and lumen were studied using a 2·9 F intravascular ultrasound catheter with a 30 MHz phased array transducer. Measurement of blood flow velocity was accomplished by a Doppler flow wire (0·018 inch). The maximal flow change during acetylcholine infusion (adjusted to 10−6; 10−5, and 10−4M concentration in the blood vessel) was measured. There were no significant differences between groups 1 and 2 with respect to age (48·5±14·3 years vs 50·3±12·3 years; P=ns), gender (4 female/8 male vs 13 female/26 male; P=ns), luminal area of the vessel segment in which the intravascular ultrasound measurements were obtained (11·8±6·1 mm2 vs 16·7±14·3 mm2; P=ns), internal diameter (3·9±1·2 mm vs 4·2±1·7 mm; P=ns), and external diameter (6·1±1·3 mm vs 6·9±2·1 mm; P=ns). Cross-sectional images of the pulmonary artery wall demonstrated a single ring with high echodensity with a thin inner layer regarded as intima in group 1. In contrast, the majority of patients (n=35/39) in group 2 demonstrated a thickening of the intimal layer and/or a disturbance of layering of the echogenic arterial wall. The relative wall thickness was higher in group 2 than in group 1 (22·5±10·4% vs 15·3±6·5% P<0·05). There were no significant correlations between pulmonary artery pressure and wall thickness pulmonary artery pressure and area change in the cardiac cycle, acetylcholine-dependent increase in pulmonary flow and morphological changes in the vessel wall. We conclude that intravascular ultrasound is capable of detecting morphological changes in the pulmonary vessel wall in pulmonary hypertension and that vessel wall hypertrophy of small pulmonary segment arteries, as detected by intravascular ultrasound, is not predictive of functional vasodilatory response of resistance vessels of the same vessel area." @default.
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• W2270892604 date "1997-12-02" @default.
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• W2270892604 title "Relationship between haemodynamics and morphology in pulmonary hypertension: A quantitative intravascular ultrasound study" @default.
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• W2270892604 doi "https://doi.org/10.1093/oxfordjournals.eurheartj.a015210" @default.
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