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- W2271005910 endingPage "197" @default.
- W2271005910 startingPage "185" @default.
- W2271005910 abstract "The aetiology of major neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) is still unknown, but increasing evidences suggest that glutamate and mitochondria are two prominent players in the oxidative stress (OS) process that underlie these illnesses. Although AD and PD have distinct pathological and clinical features, OS is a common mechanism contributing to neuronal damage. Glutamate is an important neurotransmitter in neurons and glial cells and is strongly dependent on calcium homeostasis and on mitochondrial function. In the present work we focused on glutamate- induced calcium signaling and its relation to the mitochondrial dysfunction with cell death processes. In addition, we have discussed how alterations in this pathway may lead or aggravate the neurodegenerative diseases. Finally, this review aims to stimulate further studies on this issue and thereby engage a new perspective regarding the design of possible therapeutic agents or the identification of biomarkers." @default.
- W2271005910 created "2016-06-24" @default.
- W2271005910 creator A5006233522 @default.
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- W2271005910 creator A5035421134 @default.
- W2271005910 creator A5038729121 @default.
- W2271005910 creator A5042498098 @default.
- W2271005910 date "2016-01-01" @default.
- W2271005910 modified "2023-10-18" @default.
- W2271005910 title "Glutamate and Mitochondria: Two Prominent Players in the Oxidative Stress-Induced Neurodegeneration" @default.
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