Matches in SemOpenAlex for { <https://semopenalex.org/work/W2271012246> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2271012246 endingPage "560" @default.
- W2271012246 startingPage "560" @default.
- W2271012246 abstract "2389 The lack of availability of effective drugs and acquired drug resistance are two significant problems in the treatment of bladder cancer. WP744 is a novel DNA binder that is structurally related to doxorubicin (DOX) and highly apoptotic and active against multidrug-resistant tumors of several types. We tested WP744 activity against a panel of sensitive and DOX-resistant human bladder cancer cell lines. WP744 showed 3 to 5 times the cytotoxicity of DOX against human bladder cancer cell lines UM-UC-6, UM-UC-2, UM-UC-3, and UM-UC-14. WP744 was still more cytotoxic (78-fold greater than DOX) and an effective inducer of apoptosis in the DOX-resistant variant UM-UC-6dox. WP744-induced cell growth inhibition and apoptosis seem to result from cell cycle arrest at G2/M phase. The uptake of WP744 was much faster than DOX in the both sensitive and resistant cell lines (UM-UC-6 and UM-UC-6dox). The cellular localization of WP744 was similar to that of DOX, but the nuclear concentrations of WP744 were much higher than those of DOX. We conclude that WP744 is a potent cytotoxin and inducer of apoptosis in human bladder cancer cells and can overcome resistance to DOX. These results warrant further evaluation in in vivo tumor models. This work was supported, in part, The University of Texas Genitourinary Cancer SPORE Grant (Grant NO. P50 CA91846), and by the Grant from the Welch Foundation." @default.
- W2271012246 created "2016-06-24" @default.
- W2271012246 creator A5002737792 @default.
- W2271012246 creator A5037985318 @default.
- W2271012246 creator A5055645760 @default.
- W2271012246 creator A5062959791 @default.
- W2271012246 creator A5069116689 @default.
- W2271012246 creator A5087797167 @default.
- W2271012246 date "2005-05-01" @default.
- W2271012246 modified "2023-09-23" @default.
- W2271012246 title "WP744, an novel anthracycline highly active against wild-type and doxorubicin-resistant bladder cancer cell lines" @default.
- W2271012246 hasPublicationYear "2005" @default.
- W2271012246 type Work @default.
- W2271012246 sameAs 2271012246 @default.
- W2271012246 citedByCount "0" @default.
- W2271012246 crossrefType "journal-article" @default.
- W2271012246 hasAuthorship W2271012246A5002737792 @default.
- W2271012246 hasAuthorship W2271012246A5037985318 @default.
- W2271012246 hasAuthorship W2271012246A5055645760 @default.
- W2271012246 hasAuthorship W2271012246A5062959791 @default.
- W2271012246 hasAuthorship W2271012246A5069116689 @default.
- W2271012246 hasAuthorship W2271012246A5087797167 @default.
- W2271012246 hasConcept C109316439 @default.
- W2271012246 hasConcept C121608353 @default.
- W2271012246 hasConcept C126322002 @default.
- W2271012246 hasConcept C150903083 @default.
- W2271012246 hasConcept C154317977 @default.
- W2271012246 hasConcept C190283241 @default.
- W2271012246 hasConcept C202751555 @default.
- W2271012246 hasConcept C207001950 @default.
- W2271012246 hasConcept C2776694085 @default.
- W2271012246 hasConcept C2780352672 @default.
- W2271012246 hasConcept C2781303535 @default.
- W2271012246 hasConcept C29537977 @default.
- W2271012246 hasConcept C502942594 @default.
- W2271012246 hasConcept C54355233 @default.
- W2271012246 hasConcept C55493867 @default.
- W2271012246 hasConcept C71924100 @default.
- W2271012246 hasConcept C81885089 @default.
- W2271012246 hasConcept C86803240 @default.
- W2271012246 hasConcept C96232424 @default.
- W2271012246 hasConcept C98274493 @default.
- W2271012246 hasConceptScore W2271012246C109316439 @default.
- W2271012246 hasConceptScore W2271012246C121608353 @default.
- W2271012246 hasConceptScore W2271012246C126322002 @default.
- W2271012246 hasConceptScore W2271012246C150903083 @default.
- W2271012246 hasConceptScore W2271012246C154317977 @default.
- W2271012246 hasConceptScore W2271012246C190283241 @default.
- W2271012246 hasConceptScore W2271012246C202751555 @default.
- W2271012246 hasConceptScore W2271012246C207001950 @default.
- W2271012246 hasConceptScore W2271012246C2776694085 @default.
- W2271012246 hasConceptScore W2271012246C2780352672 @default.
- W2271012246 hasConceptScore W2271012246C2781303535 @default.
- W2271012246 hasConceptScore W2271012246C29537977 @default.
- W2271012246 hasConceptScore W2271012246C502942594 @default.
- W2271012246 hasConceptScore W2271012246C54355233 @default.
- W2271012246 hasConceptScore W2271012246C55493867 @default.
- W2271012246 hasConceptScore W2271012246C71924100 @default.
- W2271012246 hasConceptScore W2271012246C81885089 @default.
- W2271012246 hasConceptScore W2271012246C86803240 @default.
- W2271012246 hasConceptScore W2271012246C96232424 @default.
- W2271012246 hasConceptScore W2271012246C98274493 @default.
- W2271012246 hasLocation W22710122461 @default.
- W2271012246 hasOpenAccess W2271012246 @default.
- W2271012246 hasPrimaryLocation W22710122461 @default.
- W2271012246 hasRelatedWork W1487171297 @default.
- W2271012246 hasRelatedWork W1989063321 @default.
- W2271012246 hasRelatedWork W1999259541 @default.
- W2271012246 hasRelatedWork W2025669082 @default.
- W2271012246 hasRelatedWork W2062921857 @default.
- W2271012246 hasRelatedWork W2065028429 @default.
- W2271012246 hasRelatedWork W2079764498 @default.
- W2271012246 hasRelatedWork W2089261056 @default.
- W2271012246 hasRelatedWork W2111254733 @default.
- W2271012246 hasRelatedWork W2253737464 @default.
- W2271012246 hasRelatedWork W2317947282 @default.
- W2271012246 hasRelatedWork W2404667176 @default.
- W2271012246 hasRelatedWork W2409513477 @default.
- W2271012246 hasRelatedWork W2553854782 @default.
- W2271012246 hasRelatedWork W2791739855 @default.
- W2271012246 hasRelatedWork W2907398425 @default.
- W2271012246 hasRelatedWork W2962904906 @default.
- W2271012246 hasRelatedWork W2969797216 @default.
- W2271012246 hasRelatedWork W3189759943 @default.
- W2271012246 hasRelatedWork W2784907567 @default.
- W2271012246 hasVolume "65" @default.
- W2271012246 isParatext "false" @default.
- W2271012246 isRetracted "false" @default.
- W2271012246 magId "2271012246" @default.
- W2271012246 workType "article" @default.