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- W2271021196 abstract "Aims/hypothesis: Increased fibrotic matrix expression in glomerular mesangial and tubular epithelial cells by generating intracellular reactive oxygen species (ROS) contributes to diabetic nephropathy. This study investigated whether antioxidant intervention by NAC could successfully alleviate indices of oxidative stress, nitrosative stress, fibrosis and apoptosis in diabetic animal kidney. Methods: Streptozotocin-induced diabetic rats were randomly assigned to two groups: diabetes treated by NAC (50 mg/kg body weight, day 1-5 per week for consecutive weeks) and diabetes treated by vehicle. Levels of superoxide, nitrate oxide, and TGF-β1 were measured. Kidneys were harvested for immunohistochemical analysis. Results: Urinary albumin excretion and systemic serum superoxide and TGF-β1 production increased significant/v in diabetic animal kidney. Histomorphometric analyses showed that mesangial cells in the diabetes groups displayed strong fibronectin, and TGF-β1 expression immunoreactivity. The same is also true for MAPK activation (phospho-ERK and phospho-p38 activation), oxidative stress (8-hydroxvguanidine expression) and nitrostative stress (ONOO-expression) in diabetic kidney. Importantly, exogenous NAC treatment attenuated diabetes-induced promotion of serum superoxide and TGF-β1 abundance and urinary protein excretion. Furthermore, NAC treatment also attenuated effectively oxidative stress and nitrostative stress of diabetic renal injury. Blockade of redox signaling via NAC treatment attenuated renal-deleterious factor (TGF-β1), which accelerates renal cell apoptosis (TUNEL staining) and fibrosis (fibronectin expression) coincided with decreased phospho-ERK and phospho-p38 expression levels in diabetic renal glomeruli. Conclusion: By manipulating oxidative stress levels, NAC may provide an alternative for the treatment of renal apoptosis and fibrosis associated with nitrosative and oxidative damage in the early diabetic kidney." @default.
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- W2271021196 date "2010-03-01" @default.
- W2271021196 modified "2023-09-24" @default.
- W2271021196 title "Control of Redox Signaling by NAC in Renal Tissue as an Alternative for Attenuating Diabetes Induction of Renal Dysfunction" @default.
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