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• W2271026306 abstract "// Aleksandra Butrym 1, 2 , Justyna Rybka 1 , Dagmara Baczyńska 3 , Rafał Poręba 4 , Kazimierz Kuliczkowski 1 , Grzegorz Mazur 4 1 Department of Hematology, Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical University, Wroclaw, Poland 2 Department of Physiology, Wroclaw Medical University, Wroclaw, Poland 3 Department of Forensic Medicine, Molecular Techniques Unit, Wroclaw Medical University, Wroclaw, Poland 4 Department of Internal, Occupational Diseases, Hypertension and Clinical Oncology, Wroclaw Medical University, Wroclaw, Poland Correspondence to: Aleksandra Butrym, e-mail: aleksandra.butrym@gmail.com Keywords: miR-29c, acute myeloid leukemia, azacitidine, response to therapy, expression Received: October 05, 2015      Accepted: January 23, 2016      Published: February 03, 2016 ABSTRACT Acute myeloid leukemia (AML) is a heterogeneous disease with different clinical course and prognosis. microRNA-29 (miR-29) family of non-coding small RNAs can play an important role in pathogenesis of AML, but also can influence response to therapy. The purpose of the study was to evaluate miR-29c expression in AML patients in relationship to clinical parameters and response to chemotherapy, including azacitidine. Materials and Methods: miR-29c expression has been analyzed using RT-PCR in 95 bone marrow specimens from newly diagnosed AML patients in comparison to 20 healthy subject. Results: We showed up-regulated miR-29c expression in AML patients which was linked also to higher risk of disease relapse after achieving complete remission. In subset of elderly AML patients treated with azacitidine, low miR-29c expression at diagnosis correlated with good response to therapy. Conclusions: miR-29c is of prognostic value and influences response to azacitidine treatment in older AML patients." @default.
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• W2271026306 date "2016-02-03" @default.
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• W2271026306 title "Clinical response to azacitidine therapy depends on microRNA-29c (miR-29c) expression in older acute myeloid leukemia (AML) patients" @default.
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• W2271026306 doi "https://doi.org/10.18632/oncotarget.7172" @default.
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