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- W2271111217 abstract "Ultraviolet blood irradiation (UBI) was extensively used in the 1940s and 1950s to treat many diseases including septicemia, pneumonia, tuberculosis, arthritis, asthma, and even poliomyelitis. The early studies were carried out by several physicians in USA and published in the American Journal of Surgery. However, with the development of antibiotics, the use of UBI declined and it has now been called the cure that time forgot. Later studies were mostly performed by Russian workers, and in other Eastern countries, and the modern view in Western countries is that UBI remains highly controversial. This review discusses the potential of UBI as an alternative approach to current methods used to treat infections, as an immune-modulating therapy and as a method for normalizing blood parameters. Low and mild doses of UV kill microorganisms by damaging the DNA, while any DNA damage in host cells can be rapidly repaired by DNA repair enzymes. However, the use of UBI to treat septicemia cannot be solely due to UV-mediated killing of bacteria in the bloodstream, as only 5-7% of blood volume needs to be treated with UV to produce the optimum benefit, and higher doses can be damaging. There may be some similarities to extracorporeal photopheresis (ECP) using psoralens and UVA irradiation. However, there are differences between UBI and ECP in that UBI tends to stimulate the immune system, while ECP tends to be immunosuppressive. With the recent emergence of bacteria that are resistant to all known antibiotics, UBI should be more investigated as an alternative approach to infections, and as an immune-modulating therapy." @default.
- W2271111217 created "2016-06-24" @default.
- W2271111217 creator A5001374433 @default.
- W2271111217 creator A5021190456 @default.
- W2271111217 creator A5060772728 @default.
- W2271111217 date "2016-04-01" @default.
- W2271111217 modified "2023-09-23" @default.
- W2271111217 title "Ultraviolet blood irradiation: Is it time to remember “the cure that time forgot”?" @default.
- W2271111217 cites W1499886609 @default.
- W2271111217 cites W1504098398 @default.
- W2271111217 cites W160757945 @default.
- W2271111217 cites W1969038611 @default.
- W2271111217 cites W1970332727 @default.
- W2271111217 cites W1973376649 @default.
- W2271111217 cites W1977867207 @default.
- W2271111217 cites W1991895904 @default.
- W2271111217 cites W1992587080 @default.
- W2271111217 cites W1995409467 @default.
- W2271111217 cites W2000791674 @default.
- W2271111217 cites W2003879194 @default.
- W2271111217 cites W2007320300 @default.
- W2271111217 cites W2007902138 @default.
- W2271111217 cites W2010937580 @default.
- W2271111217 cites W2011478193 @default.
- W2271111217 cites W2015040705 @default.
- W2271111217 cites W2019206426 @default.
- W2271111217 cites W2019451201 @default.
- W2271111217 cites W2020312473 @default.
- W2271111217 cites W2027362636 @default.
- W2271111217 cites W2029127057 @default.
- W2271111217 cites W2031928486 @default.
- W2271111217 cites W2032680778 @default.
- W2271111217 cites W2036988086 @default.
- W2271111217 cites W2037523041 @default.
- W2271111217 cites W2037532926 @default.
- W2271111217 cites W2039143717 @default.
- W2271111217 cites W2043483672 @default.
- W2271111217 cites W2045291458 @default.
- W2271111217 cites W2048436059 @default.
- W2271111217 cites W2049723631 @default.
- W2271111217 cites W2050918273 @default.
- W2271111217 cites W2059738783 @default.
- W2271111217 cites W2063559177 @default.
- W2271111217 cites W2067333277 @default.
- W2271111217 cites W2068249875 @default.
- W2271111217 cites W2069061122 @default.
- W2271111217 cites W2070755044 @default.
- W2271111217 cites W2077844381 @default.
- W2271111217 cites W2078104790 @default.
- W2271111217 cites W2085428301 @default.
- W2271111217 cites W2085641189 @default.
- W2271111217 cites W2093604352 @default.
- W2271111217 cites W2093895415 @default.
- W2271111217 cites W2108989432 @default.
- W2271111217 cites W2117535648 @default.
- W2271111217 cites W2124233093 @default.
- W2271111217 cites W2124974608 @default.
- W2271111217 cites W2134177451 @default.
- W2271111217 cites W2145111808 @default.
- W2271111217 cites W2151316024 @default.
- W2271111217 cites W2157110572 @default.
- W2271111217 cites W2159491281 @default.
- W2271111217 cites W2170998161 @default.
- W2271111217 cites W2194252555 @default.
- W2271111217 cites W2233880854 @default.
- W2271111217 cites W2317099662 @default.
- W2271111217 cites W2337557724 @default.
- W2271111217 cites W2345984197 @default.
- W2271111217 cites W2354370012 @default.
- W2271111217 cites W2403532672 @default.
- W2271111217 cites W2404962377 @default.
- W2271111217 cites W2407130106 @default.
- W2271111217 cites W2407161427 @default.
- W2271111217 cites W2408631494 @default.
- W2271111217 cites W2415497996 @default.
- W2271111217 cites W2415946262 @default.
- W2271111217 cites W2416818850 @default.
- W2271111217 cites W2416992437 @default.
- W2271111217 cites W2419310303 @default.
- W2271111217 cites W2419484681 @default.
- W2271111217 cites W2429942760 @default.
- W2271111217 cites W2438082682 @default.
- W2271111217 cites W2444555187 @default.
- W2271111217 cites W2466953912 @default.
- W2271111217 cites W295428120 @default.
- W2271111217 cites W305820758 @default.
- W2271111217 cites W38798326 @default.
- W2271111217 cites W4290209057 @default.
- W2271111217 cites W4290322883 @default.
- W2271111217 cites W4290326606 @default.
- W2271111217 doi "https://doi.org/10.1016/j.jphotobiol.2016.02.007" @default.
- W2271111217 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4783265" @default.
- W2271111217 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26894849" @default.
- W2271111217 hasPublicationYear "2016" @default.
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