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• W2271112859 abstract "We have described a number of interventions that will increase the proportion of euploid embryos that result in viable deliveries. For the male partner, omega-3 FAs and antioxidants are most critical. For the female partner, reduction of stress and the body's response to stress, exercise and weight loss for obese women, avoidance of vigorous exercise for nonobese women, cessation of smoking for 3–6 months before IVF, and avoiding alcohol are the most important. For both partners, moderate exercise and a prudent diet would also be helpful. Because of the association of oxidative stress with aging, obesity, poor semen quality, and reduced oocyte and embryo quality, increasing antioxidant intake is a good general measure for both partners, particularly those approaching or over the age of 40 years. All of the measures described also improve vascular and erectile function and will have favorable effects on long-term health. Newer interventions, such as CoQ10, are just emerging and, according to nonhuman and limited human investigations, are very promising. For those embryos that are still stressed, biomarkers such as excessive mtDNA and others being actively investigated will allow identification of those euploid embryos most likely to result in a successful outcome. Because most of these interventions are supported by a limited number of studies, further blinded and randomized trials should be carried out." @default.
• W2271112859 created "2016-06-24" @default.
• W2271112859 creator A5002108399 @default.
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• W2271112859 creator A5059643614 @default.
• W2271112859 creator A5090345459 @default.
• W2271112859 date "2016-03-01" @default.
• W2271112859 modified "2023-10-14" @default.
• W2271112859 title "Aging and the environment affect gamete and embryo potential: can we intervene?" @default.
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