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- W2271348047 abstract "Delayed gastric emptying, so called idiopathic gastroparesis was already known to be one of the main causes of non-ulcer dyspepsia.But its pathophysiologic mechanism is not known yet. To test the role of neuro-hormonal dysfunction in its pathopysiologic mechanism, we studied serum gastrin in response to the meal and fasting state. Gastrin appears to increase the frequency of the gastric pacemaker and facilitates generation of action potentials; however the net effect of gastrin is known to retard gastric emptying. To verify any relationship between delayed GET and serum gastrin level, we measured fasting and postprandial 30 and 90 minutes serum gastrin levels by RIA method in 20 patients with idiopatic gastroparesis, in 20 patients with functional dyspepsia with normal GET, and in 20 normal control subjcts. The results were as follows: The percent of isotope remaining in the stomach at 90 minutes was 86.3+8.4% in idiopathic gastroparesis, 46.5+13.9% in functional dyspepsia, and 46.9+11.9% in normal controls. Fasting serum gastrin level was 112.4+24.6 pg/ml in idiopathic gastroparesis, 53.9+7.2 pg/ml in functional dyspepsia, and 58.6+5.9 pg/ml in normal control. The fasting serum gastrin level was significantly high (p<0.05) in patients with gastroparesis than in other groups, but there was no difference between functional dyspepsia and normal control. The serum gastrin level of postprandial 30 min. was 333.1+54.1 pg/ml in gastroparesis, 149.5+21.1 pg/ml in dyspepsia, 159.1+23.7 pg/ml in contol; and serum gastrin level of postprandial 90 min. was 228.0+38. 5 pg/ml in gastroparesis, 87.3+6.3 pg/ml in dyspepsia, and 73.7+7.7 pg/ml in control. There was a statistically significant correlation between delayed GET and increased serum gastrin level, and this, in turn, indicates that gastrin may play a major role in the pathophysiology of idiopathic gastroparesis." @default.
- W2271348047 created "2016-06-24" @default.
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- W2271348047 date "1992-01-01" @default.
- W2271348047 modified "2023-09-24" @default.
- W2271348047 title "특발성 위무력증 환자군의 혈청 Gastrin 동태에 관한 연구" @default.
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