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- W2271384504 abstract "We determined whether La3+ enter human peripheral blood lymphocytes via Na+/Ca2+exchanger (measured with fura-2) We first compared the sensitivity of fura-2 with La3+ and Ca2+, . 3+ 2+ 3+ fthe result indicates that the sensitiwty of fura-2 for La is much greater than for Ca . La orms a 1:1 La3+-fura-2 complex (apparent dissociation constant =l.7xl0-12mol/L, pH 7.05).Ouabain-pretreated cells, suspended in Na+-free medium, showed that La3+ can enter human lvmphocvtes via the Na+i/Caz+ (La3 )o exchanger and is found to be about 10-12 mol/L in cells exp osed to 0.4 mmol/L La3+. Otherwise, the higher concentration (0.1 mmol/L) blocks theNa+i/Ca2+(La3+)o exch2a+nge-mediated influx of Ca2+,, but the lower concentration (0.01 mmol/L)appears to increase Ca2+ entry." @default.
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- W2271384504 date "2001-01-01" @default.
- W2271384504 modified "2023-09-28" @default.
- W2271384504 title "Na+/Ca2+ Exchange-mediated La3+ Entry in Human Lymphocytes" @default.
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