FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2271425202> ?p ?o ?g. }

• W2271425202 endingPage "41" @default.
• W2271425202 startingPage "41" @default.
• W2271425202 abstract "Adult hippocampal dentate granule neurons are generated from neural stem cells (NSCs) in the mammalian brain, and the fate specification of adult NSCs is precisely controlled by the local niches and environment, such as the subventricular zone (SVZ), dentate gyrus (DG), and Toll-like receptors (TLRs). Epigallocatechin-3-gallate (EGCG) is the main polyphenolic flavonoid in green tea that has neuroprotective activities, but there is no clear understanding of the role of EGCG in adult neurogenesis in the DG after neuroinflammation. Here, we investigate the effect and the mechanism of EGCG on adult neurogenesis impaired by lipopolysaccharides (LPS). LPS-induced neuroinflammation inhibited adult neurogenesis by suppressing the proliferation and differentiation of neural stem cells in the DG, which was indicated by the decreased number of Bromodeoxyuridine (BrdU)-, Doublecortin (DCX)- and Neuronal Nuclei (NeuN)-positive cells. In addition, microglia were recruited with activatingTLR4-NF-κB signaling in the adult hippocampus by LPS injection. Treating LPS-injured mice with EGCG restored the proliferation and differentiation of NSCs in the DG, which were decreased by LPS, and EGCG treatment also ameliorated the apoptosis of NSCs. Moreover, pro-inflammatory cytokine production induced by LPS was attenuated by EGCG treatment through modulating the TLR4-NF-κB pathway. These results illustrate that EGCG has a beneficial effect on impaired adult neurogenesis caused by LPSinduced neuroinflammation, and it may be applicable as a therapeutic agent against neurodegenerative disorders caused by inflammation." @default.
• W2271425202 created "2016-06-24" @default.
• W2271425202 creator A5003745915 @default.
• W2271425202 creator A5030550850 @default.
• W2271425202 creator A5045930336 @default.
• W2271425202 creator A5047379180 @default.
• W2271425202 creator A5067062373 @default.
• W2271425202 creator A5069098263 @default.
• W2271425202 date "2016-01-01" @default.
• W2271425202 modified "2023-10-15" @default.
• W2271425202 title "Epigallocatechin-3-gallate rescues LPS-impaired adult hippocampal neurogenesis through suppressing the TLR4-NF-κB signaling pathway in mice" @default.
• W2271425202 cites W1686797737 @default.
• W2271425202 cites W1796831866 @default.
• W2271425202 cites W191966441 @default.
• W2271425202 cites W1971442892 @default.
• W2271425202 cites W1981320774 @default.
• W2271425202 cites W1986872900 @default.
• W2271425202 cites W1988178045 @default.
• W2271425202 cites W1995188451 @default.
• W2271425202 cites W1996024251 @default.
• W2271425202 cites W1998639666 @default.
• W2271425202 cites W1998775321 @default.
• W2271425202 cites W2005952102 @default.
• W2271425202 cites W2008750119 @default.
• W2271425202 cites W2009952365 @default.
• W2271425202 cites W2011038343 @default.
• W2271425202 cites W2016509061 @default.
• W2271425202 cites W2022372660 @default.
• W2271425202 cites W2022600603 @default.
• W2271425202 cites W2023932515 @default.
• W2271425202 cites W2027048265 @default.
• W2271425202 cites W2031492796 @default.
• W2271425202 cites W2031809301 @default.
• W2271425202 cites W2033906528 @default.
• W2271425202 cites W2038820792 @default.
• W2271425202 cites W2051183970 @default.
• W2271425202 cites W2053670265 @default.
• W2271425202 cites W2055298956 @default.
• W2271425202 cites W2064291612 @default.
• W2271425202 cites W2070726738 @default.
• W2271425202 cites W2070785261 @default.
• W2271425202 cites W2074918247 @default.
• W2271425202 cites W2076654506 @default.
• W2271425202 cites W2077627257 @default.
• W2271425202 cites W2079819775 @default.
• W2271425202 cites W2084652820 @default.
• W2271425202 cites W2085662515 @default.
• W2271425202 cites W2087170622 @default.
• W2271425202 cites W2092427927 @default.
• W2271425202 cites W2094923592 @default.
• W2271425202 cites W2105086774 @default.
• W2271425202 cites W2105619265 @default.
• W2271425202 cites W2106860587 @default.
• W2271425202 cites W2119707412 @default.
• W2271425202 cites W2123663795 @default.
• W2271425202 cites W2137858314 @default.
• W2271425202 cites W2141974601 @default.
• W2271425202 cites W2146140940 @default.
• W2271425202 cites W2149940207 @default.
• W2271425202 cites W2151400960 @default.
• W2271425202 cites W2151781726 @default.
• W2271425202 cites W2156649223 @default.
• W2271425202 cites W2157137975 @default.
• W2271425202 cites W2158265368 @default.
• W2271425202 cites W2159202946 @default.
• W2271425202 cites W2172266256 @default.
• W2271425202 cites W2270951111 @default.
• W2271425202 cites W2906916700 @default.
• W2271425202 doi "https://doi.org/10.4196/kjpp.2016.20.1.41" @default.
• W2271425202 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4722190" @default.
• W2271425202 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26807022" @default.
• W2271425202 hasPublicationYear "2016" @default.
• W2271425202 type Work @default.
• W2271425202 sameAs 2271425202 @default.
• W2271425202 citedByCount "59" @default.
• W2271425202 countsByYear W22714252022017 @default.
• W2271425202 countsByYear W22714252022018 @default.
• W2271425202 countsByYear W22714252022019 @default.
• W2271425202 countsByYear W22714252022020 @default.
• W2271425202 countsByYear W22714252022021 @default.
• W2271425202 countsByYear W22714252022022 @default.
• W2271425202 countsByYear W22714252022023 @default.
• W2271425202 crossrefType "journal-article" @default.
• W2271425202 hasAuthorship W2271425202A5003745915 @default.
• W2271425202 hasAuthorship W2271425202A5030550850 @default.
• W2271425202 hasAuthorship W2271425202A5045930336 @default.
• W2271425202 hasAuthorship W2271425202A5047379180 @default.
• W2271425202 hasAuthorship W2271425202A5067062373 @default.
• W2271425202 hasAuthorship W2271425202A5069098263 @default.
• W2271425202 hasBestOaLocation W22714252021 @default.
• W2271425202 hasConcept C136834591 @default.
• W2271425202 hasConcept C148762608 @default.
• W2271425202 hasConcept C169760540 @default.
• W2271425202 hasConcept C185592680 @default.
• W2271425202 hasConcept C203014093 @default.
• W2271425202 hasConcept C204232928 @default.
• W2271425202 hasConcept C25498285 @default.
• W2271425202 hasConcept C2776070231 @default.

• next