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- W2271546773 abstract "Coronaviruses have been closely related with mankind for thousands of years. Community-acquired human coronaviruses have long been recognized to cause common cold. However, zoonotic coronaviruses are now becoming more a global concern with the discovery of highly pathogenic severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronaviruses causing severe respiratory diseases. Infections by these emerging human coronaviruses are characterized by less robust interferon production. Treatment of patients with recombinant interferon regimen promises beneficial outcomes, suggesting that compromised interferon expression might contribute at least partially to the severity of disease. The mechanisms by which coronaviruses evade host innate antiviral response are under intense investigations. This review focuses on the fierce arms race between host innate antiviral immunity and emerging human coronaviruses. Particularly, the host pathogen recognition receptors and the signal transduction pathways to mount an effective antiviral response against SARS and MERS coronavirus infection are discussed. On the other hand, the counter-measures evolved by SARS and MERS coronaviruses to circumvent host defense are also dissected. With a better understanding of the dynamic interaction between host and coronaviruses, it is hoped that insights on the pathogenesis of newly-identified highly pathogenic human coronaviruses and new strategies in antiviral development can be derived." @default.
- W2271546773 created "2016-06-24" @default.
- W2271546773 creator A5028951688 @default.
- W2271546773 creator A5058253076 @default.
- W2271546773 creator A5063203922 @default.
- W2271546773 date "2016-01-15" @default.
- W2271546773 modified "2023-10-05" @default.
- W2271546773 title "A molecular arms race between host innate antiviral response and emerging human coronaviruses" @default.
- W2271546773 cites W1151195487 @default.
- W2271546773 cites W1560860164 @default.
- W2271546773 cites W1828394588 @default.
- W2271546773 cites W1929156901 @default.
- W2271546773 cites W1965411122 @default.
- W2271546773 cites W1966238900 @default.
- W2271546773 cites W1969841753 @default.
- W2271546773 cites W1972784345 @default.
- W2271546773 cites W1973610263 @default.
- W2271546773 cites W1973646620 @default.
- W2271546773 cites W1976400886 @default.
- W2271546773 cites W1976483167 @default.
- W2271546773 cites W1977050884 @default.
- W2271546773 cites W1979623919 @default.
- W2271546773 cites W1984494056 @default.
- W2271546773 cites W1990000646 @default.
- W2271546773 cites W1994034344 @default.
- W2271546773 cites W1995296637 @default.
- W2271546773 cites W1996523417 @default.
- W2271546773 cites W1996909392 @default.
- W2271546773 cites W1997713382 @default.
- W2271546773 cites W1997876081 @default.
- W2271546773 cites W1999050752 @default.
- W2271546773 cites W1999716303 @default.
- W2271546773 cites W2000177767 @default.
- W2271546773 cites W2005081670 @default.
- W2271546773 cites W2005094081 @default.
- W2271546773 cites W2008811126 @default.
- W2271546773 cites W2009882421 @default.
- W2271546773 cites W2022183964 @default.
- W2271546773 cites W2025583562 @default.
- W2271546773 cites W2026362729 @default.
- W2271546773 cites W2027518730 @default.
- W2271546773 cites W2029831111 @default.
- W2271546773 cites W2034133457 @default.
- W2271546773 cites W2034736009 @default.
- W2271546773 cites W2035299766 @default.
- W2271546773 cites W2037805800 @default.
- W2271546773 cites W2041802815 @default.
- W2271546773 cites W2043064608 @default.
- W2271546773 cites W2047365750 @default.
- W2271546773 cites W2049537492 @default.
- W2271546773 cites W2049924342 @default.
- W2271546773 cites W2049975503 @default.
- W2271546773 cites W2050843600 @default.
- W2271546773 cites W2052108354 @default.
- W2271546773 cites W2053503974 @default.
- W2271546773 cites W2053665358 @default.
- W2271546773 cites W2058277625 @default.
- W2271546773 cites W2060027762 @default.
- W2271546773 cites W2060197609 @default.
- W2271546773 cites W2064961188 @default.
- W2271546773 cites W2065360219 @default.
- W2271546773 cites W2068824485 @default.
- W2271546773 cites W2069902539 @default.
- W2271546773 cites W2071680235 @default.
- W2271546773 cites W2078889234 @default.
- W2271546773 cites W2078917493 @default.
- W2271546773 cites W2085053457 @default.
- W2271546773 cites W2085510519 @default.
- W2271546773 cites W2086779557 @default.
- W2271546773 cites W2088138646 @default.
- W2271546773 cites W2092162071 @default.
- W2271546773 cites W2092969802 @default.
- W2271546773 cites W2096261947 @default.
- W2271546773 cites W2097188280 @default.
- W2271546773 cites W2099866950 @default.
- W2271546773 cites W2100665873 @default.
- W2271546773 cites W2102229939 @default.
- W2271546773 cites W2103208261 @default.
- W2271546773 cites W2105637133 @default.
- W2271546773 cites W2107458751 @default.
- W2271546773 cites W2108046273 @default.
- W2271546773 cites W2109491705 @default.
- W2271546773 cites W2109618330 @default.
- W2271546773 cites W2109686486 @default.
- W2271546773 cites W2111412754 @default.
- W2271546773 cites W2112147913 @default.
- W2271546773 cites W2116586125 @default.
- W2271546773 cites W2117266879 @default.
- W2271546773 cites W2118694630 @default.
- W2271546773 cites W2118926211 @default.
- W2271546773 cites W2119111857 @default.
- W2271546773 cites W2119426024 @default.
- W2271546773 cites W2119885778 @default.
- W2271546773 cites W2132056320 @default.
- W2271546773 cites W2132403605 @default.
- W2271546773 cites W2133402546 @default.
- W2271546773 cites W2136329789 @default.
- W2271546773 cites W2137888434 @default.