FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2271546904> ?p ?o ?g. }

• W2271546904 endingPage "117" @default.
• W2271546904 startingPage "110" @default.
• W2271546904 abstract "For the past 60 years a major theory of “aging” is that age-related damage is largely caused by excessive uncompensated oxidative stress. The ubiquitous tripeptide glutathione is a major antioxidant defense mechanism against reactive free radicals and has also served as a marker of changes in oxidative stress. Some (albeit conflicting) animal data suggest a loss of glutathione in brain senescence, which might compromise the ability of the aging brain to meet the demands of oxidative stress. Our objective was to establish whether advancing age is associated with glutathione deficiency in human brain. We measured reduced glutathione (GSH) levels in multiple regions of autopsied brain of normal subjects (n=74) aged one day to 99 years. Brain GSH levels during the infancy/teenage years were generally similar to those in the oldest examined adult group (76–99 years). During adulthood (23–99 years) GSH levels remained either stable (occipital cortex) or increased (caudate nucleus, frontal and cerebellar cortices). To the extent that GSH levels represent glutathione antioxidant capacity, our postmortem data suggest that human brain aging is not associated with declining glutathione status. We suggest that aged healthy human brains can maintain antioxidant capacity related to glutathione and that an age-related increase in GSH levels in some brain regions might possibly be a compensatory response to increased oxidative stress. Since our findings, although suggestive, suffer from the generic limitations of all postmortem brain studies, we also suggest the need for “replication” investigations employing the new 1H MRS imaging procedures in living human brain." @default.
• W2271546904 created "2016-06-24" @default.
• W2271546904 creator A5000210550 @default.
• W2271546904 creator A5002685324 @default.
• W2271546904 creator A5021103203 @default.
• W2271546904 creator A5032878650 @default.
• W2271546904 creator A5055378951 @default.
• W2271546904 creator A5063108898 @default.
• W2271546904 creator A5063648717 @default.
• W2271546904 creator A5070723808 @default.
• W2271546904 creator A5088982444 @default.
• W2271546904 date "2016-04-01" @default.
• W2271546904 modified "2023-10-15" @default.
• W2271546904 title "Do glutathione levels decline in aging human brain?" @default.
• W2271546904 cites W149805343 @default.
• W2271546904 cites W1509408588 @default.
• W2271546904 cites W1526123135 @default.
• W2271546904 cites W1533236567 @default.
• W2271546904 cites W1792160104 @default.
• W2271546904 cites W186344272 @default.
• W2271546904 cites W1932056767 @default.
• W2271546904 cites W1964433896 @default.
• W2271546904 cites W1965344368 @default.
• W2271546904 cites W1966001930 @default.
• W2271546904 cites W1967013632 @default.
• W2271546904 cites W1967442508 @default.
• W2271546904 cites W1970836174 @default.
• W2271546904 cites W1971169887 @default.
• W2271546904 cites W1972899609 @default.
• W2271546904 cites W1977817124 @default.
• W2271546904 cites W1978183586 @default.
• W2271546904 cites W1978933175 @default.
• W2271546904 cites W1979738017 @default.
• W2271546904 cites W1980424915 @default.
• W2271546904 cites W1981124126 @default.
• W2271546904 cites W1983619465 @default.
• W2271546904 cites W1984900551 @default.
• W2271546904 cites W1984940419 @default.
• W2271546904 cites W1991117877 @default.
• W2271546904 cites W1992186082 @default.
• W2271546904 cites W1995639654 @default.
• W2271546904 cites W1997271041 @default.
• W2271546904 cites W1997400309 @default.
• W2271546904 cites W1999469877 @default.
• W2271546904 cites W2000724486 @default.
• W2271546904 cites W2003867505 @default.
• W2271546904 cites W2004280801 @default.
• W2271546904 cites W2005839583 @default.
• W2271546904 cites W2006165069 @default.
• W2271546904 cites W2008303144 @default.
• W2271546904 cites W2015850772 @default.
• W2271546904 cites W2016562224 @default.
• W2271546904 cites W2017026767 @default.
• W2271546904 cites W2018542393 @default.
• W2271546904 cites W2023677185 @default.
• W2271546904 cites W2027928909 @default.
• W2271546904 cites W2029182510 @default.
• W2271546904 cites W2032213742 @default.
• W2271546904 cites W2032658516 @default.
• W2271546904 cites W2035223100 @default.
• W2271546904 cites W2036561640 @default.
• W2271546904 cites W2039518578 @default.
• W2271546904 cites W2046121463 @default.
• W2271546904 cites W2053244223 @default.
• W2271546904 cites W2054215417 @default.
• W2271546904 cites W2056620406 @default.
• W2271546904 cites W2060011496 @default.
• W2271546904 cites W2061658901 @default.
• W2271546904 cites W2062669701 @default.
• W2271546904 cites W2067565438 @default.
• W2271546904 cites W2075417836 @default.
• W2271546904 cites W2077567337 @default.
• W2271546904 cites W2078497313 @default.
• W2271546904 cites W2078924245 @default.
• W2271546904 cites W2085577787 @default.
• W2271546904 cites W2092517899 @default.
• W2271546904 cites W2104644601 @default.
• W2271546904 cites W2105549490 @default.
• W2271546904 cites W2105594072 @default.
• W2271546904 cites W2111478295 @default.
• W2271546904 cites W2113675370 @default.
• W2271546904 cites W2115817059 @default.
• W2271546904 cites W2120864024 @default.
• W2271546904 cites W2133141500 @default.
• W2271546904 cites W2148512456 @default.
• W2271546904 cites W2152975037 @default.
• W2271546904 cites W2154489578 @default.
• W2271546904 cites W2164498176 @default.
• W2271546904 cites W2169714384 @default.
• W2271546904 cites W2187106138 @default.
• W2271546904 cites W2315512556 @default.
• W2271546904 cites W2336893408 @default.
• W2271546904 cites W810755047 @default.
• W2271546904 doi "https://doi.org/10.1016/j.freeradbiomed.2016.01.029" @default.
• W2271546904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26845616" @default.
• W2271546904 hasPublicationYear "2016" @default.
• W2271546904 type Work @default.
• W2271546904 sameAs 2271546904 @default.

• next