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- W2271594585 abstract "The profound scientific and commercial success of molecular biology, the progress of ‘cancer gene’ investigation technologies, together, pushed forward the postulate that genes explain ‘everything’. Yet, during the last few years the microenvironments of solid tumors have emerged as key modulators of initiation, progression and metastasis and as essential to the therapeutic response. In the present review, we provide a synthetic examination of the main traits of cells embedded into the cancer stroma and emphasize several evidences that all components of the tumor tissue cooperate in space and time. Then we turn to discuss the epitheliocentric somatic mutational view and other new paradigms assuming that disturbed tissue interactions among cell populations are critical to cancer causation, growth and spread." @default.
- W2271594585 created "2016-06-24" @default.
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- W2271594585 date "2016-03-01" @default.
- W2271594585 modified "2023-09-23" @default.
- W2271594585 title "Cancer as a changed tissue's way of life (when to treat, when to watch and when to think)" @default.
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- W2271594585 doi "https://doi.org/10.2217/fon.15.336" @default.
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