FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2271750147> ?p ?o ?g. }

• W2271750147 endingPage "1299" @default.
• W2271750147 startingPage "1291" @default.
• W2271750147 abstract "Humanized mice harboring human immune systems (HIS) represent a platform to study immune responses against pathogens and to screen vaccine candidates and novel immunotherapeutics. Innate and adaptive immune responses are suboptimal in HIS mice, possibly due to poor reconstitution of human antigen-presenting cells, including dendritic cells (DCs). DC homeostasis is regulated by cytokine availability, and Flt3-ligand (Flt3L) is one factor that conditions this process. Mouse myelopoiesis is essentially normal in most current HIS models. As such, developing mouse myeloid cells may limit human DC reconstitution by reducing available Flt3L and by cellular competition for specific niches. To address these issues, we created a novel HIS model that compromises host myeloid cell development via deficiency in the receptor tyrosine kinase Flk2/Flt3. In Balb/c Rag2(-/-) Il2rg(-/-) Flt3(-/-) (BRGF) recipients, human conventional DCs and plasmacytoid DCs develop from hCD34(+) precursors and can be specifically boosted with exogenous Flt3L. Human DCs that develop in this context normally respond to TLR stimulation, and improved human DC homeostasis is associated with increased numbers of human NK and T cells. This new HIS-DC model should provide a means to dissect human DC differentiation and represents a novel platform to screen immune adjuvants and DC targeting therapies." @default.
• W2271750147 created "2016-06-24" @default.
• W2271750147 creator A5000888675 @default.
• W2271750147 creator A5001213113 @default.
• W2271750147 creator A5032817893 @default.
• W2271750147 creator A5038805449 @default.
• W2271750147 creator A5046918805 @default.
• W2271750147 creator A5054903259 @default.
• W2271750147 creator A5070460836 @default.
• W2271750147 creator A5077707305 @default.
• W2271750147 creator A5083003001 @default.
• W2271750147 creator A5089955013 @default.
• W2271750147 date "2016-03-01" @default.
• W2271750147 modified "2023-10-10" @default.
• W2271750147 title "A novel Flt3-deficient HIS mouse model with selective enhancement of human DC development" @default.
• W2271750147 cites W1561765753 @default.
• W2271750147 cites W1624846170 @default.
• W2271750147 cites W1640609747 @default.
• W2271750147 cites W1858218633 @default.
• W2271750147 cites W1927758176 @default.
• W2271750147 cites W1971833736 @default.
• W2271750147 cites W1976820932 @default.
• W2271750147 cites W1980005768 @default.
• W2271750147 cites W1985020869 @default.
• W2271750147 cites W1989712520 @default.
• W2271750147 cites W1992439632 @default.
• W2271750147 cites W2006496065 @default.
• W2271750147 cites W2007987850 @default.
• W2271750147 cites W2041515126 @default.
• W2271750147 cites W2071153515 @default.
• W2271750147 cites W2073489229 @default.
• W2271750147 cites W2081386812 @default.
• W2271750147 cites W2083894535 @default.
• W2271750147 cites W2090685407 @default.
• W2271750147 cites W2099789019 @default.
• W2271750147 cites W2100820895 @default.
• W2271750147 cites W2101758099 @default.
• W2271750147 cites W2102777952 @default.
• W2271750147 cites W2114530568 @default.
• W2271750147 cites W2144980184 @default.
• W2271750147 cites W2146432917 @default.
• W2271750147 cites W2150753841 @default.
• W2271750147 cites W2155792963 @default.
• W2271750147 cites W2156831625 @default.
• W2271750147 cites W2157562991 @default.
• W2271750147 cites W2166045197 @default.
• W2271750147 cites W2170933182 @default.
• W2271750147 cites W3043125680 @default.
• W2271750147 doi "https://doi.org/10.1002/eji.201546132" @default.
• W2271750147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26865269" @default.
• W2271750147 hasPublicationYear "2016" @default.
• W2271750147 type Work @default.
• W2271750147 sameAs 2271750147 @default.
• W2271750147 citedByCount "50" @default.
• W2271750147 countsByYear W22717501472017 @default.
• W2271750147 countsByYear W22717501472018 @default.
• W2271750147 countsByYear W22717501472019 @default.
• W2271750147 countsByYear W22717501472020 @default.
• W2271750147 countsByYear W22717501472021 @default.
• W2271750147 countsByYear W22717501472022 @default.
• W2271750147 countsByYear W22717501472023 @default.
• W2271750147 crossrefType "journal-article" @default.
• W2271750147 hasAuthorship W2271750147A5000888675 @default.
• W2271750147 hasAuthorship W2271750147A5001213113 @default.
• W2271750147 hasAuthorship W2271750147A5032817893 @default.
• W2271750147 hasAuthorship W2271750147A5038805449 @default.
• W2271750147 hasAuthorship W2271750147A5046918805 @default.
• W2271750147 hasAuthorship W2271750147A5054903259 @default.
• W2271750147 hasAuthorship W2271750147A5070460836 @default.
• W2271750147 hasAuthorship W2271750147A5077707305 @default.
• W2271750147 hasAuthorship W2271750147A5083003001 @default.
• W2271750147 hasAuthorship W2271750147A5089955013 @default.
• W2271750147 hasBestOaLocation W22717501471 @default.
• W2271750147 hasConcept C104317684 @default.
• W2271750147 hasConcept C109159458 @default.
• W2271750147 hasConcept C127716648 @default.
• W2271750147 hasConcept C151730666 @default.
• W2271750147 hasConcept C193419808 @default.
• W2271750147 hasConcept C203014093 @default.
• W2271750147 hasConcept C2778170410 @default.
• W2271750147 hasConcept C2779282312 @default.
• W2271750147 hasConcept C2779343474 @default.
• W2271750147 hasConcept C2779919695 @default.
• W2271750147 hasConcept C28328180 @default.
• W2271750147 hasConcept C55493867 @default.
• W2271750147 hasConcept C86803240 @default.
• W2271750147 hasConcept C8891405 @default.
• W2271750147 hasConcept C95444343 @default.
• W2271750147 hasConcept C95862172 @default.
• W2271750147 hasConceptScore W2271750147C104317684 @default.
• W2271750147 hasConceptScore W2271750147C109159458 @default.
• W2271750147 hasConceptScore W2271750147C127716648 @default.
• W2271750147 hasConceptScore W2271750147C151730666 @default.
• W2271750147 hasConceptScore W2271750147C193419808 @default.
• W2271750147 hasConceptScore W2271750147C203014093 @default.
• W2271750147 hasConceptScore W2271750147C2778170410 @default.
• W2271750147 hasConceptScore W2271750147C2779282312 @default.
• W2271750147 hasConceptScore W2271750147C2779343474 @default.

• next