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• W2271842838 startingPage "945" @default.
• W2271842838 abstract "Abstract While the cellular sources for granulocyte-macrophage colony- stimulating factor (GM-CSF) are known to be widely distributed among several cell types, interleukin-3 (IL-3) gene expression has been demonstrated in only certain T-cell clones and in blood mononuclear cells stimulated with phytohemagglutinin (PHA) and phorbol-myristate- acetate (PMA). To determine which blood cells were responsible for this expression, we fractionated PHA/PMA-stimulated mononuclear cells and identified T lymphocytes as the source of IL-3 mRNA. Low-level IL-3 expression was detected as well in several stimulated human T-cell lines. Hematopoietic stromal cells such as fibroblasts and endothelial cells could not be induced to express IL-3 mRNA. The kinetics of IL-3 mRNA induction in mononuclear cells and lymphocytes stimulated with PHA/PMA or anti-CD3 monoclonal antibody (MoAb) and interleukin-1 (IL-1) were similar to those observed for GM-CSF expression." @default.
• W2271842838 created "2016-06-24" @default.
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• W2271842838 date "1989-03-01" @default.
• W2271842838 modified "2023-10-16" @default.
• W2271842838 title "Expression of human interleukin-3 (multi-CSF) is restricted to human lymphocytes and T-cell tumor lines" @default.
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• W2271842838 doi "https://doi.org/10.1182/blood.v73.4.945.945" @default.
• W2271842838 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2645952" @default.
• W2271842838 hasPublicationYear "1989" @default.
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