FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2271844845> ?p ?o ?g. }

• W2271844845 endingPage "55" @default.
• W2271844845 startingPage "44" @default.
• W2271844845 abstract "Abstract Objective To determine histologic and immunohistochemical predictors of metastasis of feline diffuse iris melanoma (FDIM). Animals Globes from 47 client‐owned cats enucleated for FDIM between January 1985 and December 2013. Procedures Hematoxylin and eosin‐stained sections were evaluated for neoplastic invasiveness and cell morphology, necrosis within the neoplasm, inflammation, and glaucoma. Sections were immunolabeled with antibodies against melan‐A, PNL2, E‐cadherin, or B‐Raf, and label intensity, percentage of labeled cells, and label homogeneity were semi‐quantitatively graded. Medical records were evaluated, and referring veterinarians and clients were contacted to determine whether cats developed metastasis following enucleation. The log‐rank test or Cox proportional hazards model was used to determine associations between histologic or immunohistochemical parameters and metastasis. Results Metastasis was suspected or confirmed in 9/47 (19%) cats. Extrascleral extension, necrosis within the neoplasm, a mitotic index of >7 mitoses in 10 high‐power (×400) fields, choroidal invasion, and increased E‐cadherin and melan‐A label intensity were each associated with increased rate of metastasis. PNL2 label homogeneity was associated with decreased rate of metastasis. Decreased PNL2 label intensity and an increasing percentage of neoplastic cells labeled for melan‐A each approached significance for increased rate of metastasis. Conclusions We report four histologic and three immunohistochemical parameters helpful in determining cats at risk of metastasis of FDIM. Further studies should determine if B‐Raf mutations identified in human malignant melanomas are found in cats with FDIM and assess benefits of adjunctive therapy following enucleation of eyes with FDIM bearing poor prognostic indicators." @default.
• W2271844845 created "2016-06-24" @default.
• W2271844845 creator A5010029612 @default.
• W2271844845 creator A5018444610 @default.
• W2271844845 creator A5024968889 @default.
• W2271844845 creator A5063211464 @default.
• W2271844845 date "2016-01-24" @default.
• W2271844845 modified "2023-10-07" @default.
• W2271844845 title "Histologic and immunohistochemical predictors of clinical behavior for feline diffuse iris melanoma" @default.
• W2271844845 cites W1549808030 @default.
• W2271844845 cites W1968379106 @default.
• W2271844845 cites W1974443079 @default.
• W2271844845 cites W1978587344 @default.
• W2271844845 cites W1978708888 @default.
• W2271844845 cites W1992847016 @default.
• W2271844845 cites W1993621828 @default.
• W2271844845 cites W1996119746 @default.
• W2271844845 cites W2000220337 @default.
• W2271844845 cites W2000255330 @default.
• W2271844845 cites W2014809463 @default.
• W2271844845 cites W2017648326 @default.
• W2271844845 cites W2024249554 @default.
• W2271844845 cites W2027158717 @default.
• W2271844845 cites W2030090912 @default.
• W2271844845 cites W2035831878 @default.
• W2271844845 cites W2038434969 @default.
• W2271844845 cites W2050299776 @default.
• W2271844845 cites W2051116464 @default.
• W2271844845 cites W2057663047 @default.
• W2271844845 cites W2065784961 @default.
• W2271844845 cites W2078011935 @default.
• W2271844845 cites W2081527131 @default.
• W2271844845 cites W2086907623 @default.
• W2271844845 cites W2088113039 @default.
• W2271844845 cites W2090654162 @default.
• W2271844845 cites W2096637524 @default.
• W2271844845 cites W2100592997 @default.
• W2271844845 cites W2102367225 @default.
• W2271844845 cites W2103025086 @default.
• W2271844845 cites W2109511835 @default.
• W2271844845 cites W2110664446 @default.
• W2271844845 cites W2124455968 @default.
• W2271844845 cites W2130894486 @default.
• W2271844845 cites W2135000275 @default.
• W2271844845 cites W2136437802 @default.
• W2271844845 cites W2141456229 @default.
• W2271844845 cites W2148102754 @default.
• W2271844845 cites W2163188200 @default.
• W2271844845 cites W2166559064 @default.
• W2271844845 cites W3021610273 @default.
• W2271844845 doi "https://doi.org/10.1111/vop.12344" @default.
• W2271844845 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26805705" @default.
• W2271844845 hasPublicationYear "2016" @default.
• W2271844845 type Work @default.
• W2271844845 sameAs 2271844845 @default.
• W2271844845 citedByCount "26" @default.
• W2271844845 countsByYear W22718448452016 @default.
• W2271844845 countsByYear W22718448452017 @default.
• W2271844845 countsByYear W22718448452018 @default.
• W2271844845 countsByYear W22718448452019 @default.
• W2271844845 countsByYear W22718448452020 @default.
• W2271844845 countsByYear W22718448452021 @default.
• W2271844845 countsByYear W22718448452022 @default.
• W2271844845 countsByYear W22718448452023 @default.
• W2271844845 crossrefType "journal-article" @default.
• W2271844845 hasAuthorship W2271844845A5010029612 @default.
• W2271844845 hasAuthorship W2271844845A5018444610 @default.
• W2271844845 hasAuthorship W2271844845A5024968889 @default.
• W2271844845 hasAuthorship W2271844845A5063211464 @default.
• W2271844845 hasBestOaLocation W22718448452 @default.
• W2271844845 hasConcept C121608353 @default.
• W2271844845 hasConcept C125473707 @default.
• W2271844845 hasConcept C126322002 @default.
• W2271844845 hasConcept C141071460 @default.
• W2271844845 hasConcept C142160229 @default.
• W2271844845 hasConcept C142724271 @default.
• W2271844845 hasConcept C188261085 @default.
• W2271844845 hasConcept C204232928 @default.
• W2271844845 hasConcept C2777658100 @default.
• W2271844845 hasConcept C2779013556 @default.
• W2271844845 hasConcept C2779904517 @default.
• W2271844845 hasConcept C2780635560 @default.
• W2271844845 hasConcept C502942594 @default.
• W2271844845 hasConcept C71924100 @default.
• W2271844845 hasConceptScore W2271844845C121608353 @default.
• W2271844845 hasConceptScore W2271844845C125473707 @default.
• W2271844845 hasConceptScore W2271844845C126322002 @default.
• W2271844845 hasConceptScore W2271844845C141071460 @default.
• W2271844845 hasConceptScore W2271844845C142160229 @default.
• W2271844845 hasConceptScore W2271844845C142724271 @default.
• W2271844845 hasConceptScore W2271844845C188261085 @default.
• W2271844845 hasConceptScore W2271844845C204232928 @default.
• W2271844845 hasConceptScore W2271844845C2777658100 @default.
• W2271844845 hasConceptScore W2271844845C2779013556 @default.
• W2271844845 hasConceptScore W2271844845C2779904517 @default.
• W2271844845 hasConceptScore W2271844845C2780635560 @default.
• W2271844845 hasConceptScore W2271844845C502942594 @default.
• W2271844845 hasConceptScore W2271844845C71924100 @default.

• next