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- W2271937585 abstract "The in vitro effect of bisphenol A (BPA) on ovarian steroidogenesis of the longchin goby (Chasmichthys dolichognathus) was investigated. Oocytes taken during the maturing phase (vitellogenic, fully vitellogenic or germinal vesicle breakdown stage) were incubated with BPA (100 ng/mL) in the presence of exogenous precursor ³H-17α hydroxyprogesterone (³H-17αOHP). Steroids were extracted from the media and the isolated oocytes, and the extracts were separated and identified by thin layer chromatography and gas chromatography-mass spectrometry. The identities of the major metabolites were progestogens [17α-hydroxy,20adihydroprogesterone (17α20αOHP) and 17α-hydroxy,20β-dihydroprogesterone (17α20βOHP)], androgens [androstenedione (A4) and testosterone (T)] and estrogens [estrone (E₁) and estradiol-17β (E₂)]. BPA treatment inhibited production of estrogens in all the maturing phases and progestogens in the germinal vesicle migrating stage. Percentage yield of estrogens was decreased with increased yield of androgens. In conclusion, BPA had an inhibitory effect on the conversion of ³H-17αOHP to estrogens and progestogens. These results demonstrate that BPA can act either estrogenic or anti-estrogenic effects." @default.
- W2271937585 created "2016-06-24" @default.
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- W2271937585 date "2004-06-01" @default.
- W2271937585 modified "2023-09-24" @default.
- W2271937585 title "Bisphenol A가 점망둑 (Chasmichthys dolichognathus)의 난소 스테로이드 호르몬 대사에 미치는 영향" @default.
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