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- W2271962956 abstract "Using high throughput screening-compatible assays for superoxide and hydrogen peroxide, we identified potential inhibitors of the NADPH oxidase (Nox2) isoform from a small library of bioactive compounds. By using multiple probes (hydroethidine, hydropropidine, Amplex Red, and coumarin boronate) with well defined redox chemistry that form highly diagnostic marker products upon reaction with superoxide (O2 ()), hydrogen peroxide (H2O2), and peroxynitrite (ONOO(-)), the number of false positives was greatly decreased. Selected hits for Nox2 were further screened for their ability to inhibit ONOO(-)formation in activated macrophages. A new diagnostic marker product for ONOO(-)is reported. We conclude that the newly developed high throughput screening/reactive oxygen species assays could also be used to identify potential inhibitors of ONOO(-)formed from Nox2-derived O2 ()and nitric oxide synthase-derived nitric oxide." @default.
- W2271962956 created "2016-06-24" @default.
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- W2271962956 date "2016-03-01" @default.
- W2271962956 modified "2023-10-16" @default.
- W2271962956 title "Mitigation of NADPH Oxidase 2 Activity as a Strategy to Inhibit Peroxynitrite Formation" @default.
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- W2271962956 doi "https://doi.org/10.1074/jbc.m115.702787" @default.
- W2271962956 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4807286" @default.
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