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- W2272060087 abstract "It has been evidenced that mitochondrial uncoupling protein 4 (UCP4) and ATP-regulated potassium channel (mKATP channel) of insect Gromphadorhina coqereliana mitochondria decrease superoxide anion production. We elucidated whether the two energy-dissipating systems work together on a modulation of superoxide level in cockroach mitochondria. Our data show that the simultaneous activation of UCP4 by palmitic acid and mKATP channel by pinacidil revealed a cumulative effect on weakening mitochondrial superoxide formation. The inhibition of UCP4 by GTP (and/or ATP) and mKATP channel by ATP elevated superoxide production. These results suggest a functional cooperation of both energy-dissipating systems in protection against oxidative stress in insects." @default.
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- W2272060087 date "2015-11-30" @default.
- W2272060087 modified "2023-10-18" @default.
- W2272060087 title "Activation of Mitochondrial Uncoupling Protein 4 and ATP-Sensitive Potassium Channel Cumulatively Decreases Superoxide Production in Insect Mitochondria" @default.
- W2272060087 doi "https://doi.org/10.2174/0929866523666151106121943" @default.
- W2272060087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26548865" @default.
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