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- W2272060897 endingPage "661" @default.
- W2272060897 startingPage "653" @default.
- W2272060897 abstract "Microtubule associated protein tau, a protein mainly expressed in neurons, plays an important role in several diseases related to dementia, named tauopathies. Alzheimer disease is the most relevant tauopathy. The role of tau protein in dementia is now a topic under discussion, and is the focus of this review.We have covered two major areas: tau pathology and tau as a therapeutic target. Tau pathology is mainly related to a gain of toxic function due to an abnormal accumulation, aberrant modifications (such as hyperphosphorylation and truncation, among others) and self-aggregation of tau into oligomers or larger structures. Also, tau can be found extracellularly in a toxic form. Tau-based therapy is mainly centered on avoiding the gain of these toxic functions of tau.Tau therapies are focused on lowering tau levels, mainly of modified tau species that could be toxic for neurons (phosphorylated, truncated or aggregated tau), in intracellular or extracellular form. Decreasing the levels of those toxic species is a possible therapeutic strategy." @default.
- W2272060897 created "2016-06-24" @default.
- W2272060897 creator A5058235570 @default.
- W2272060897 creator A5063896819 @default.
- W2272060897 creator A5068673762 @default.
- W2272060897 creator A5079838423 @default.
- W2272060897 creator A5084018006 @default.
- W2272060897 date "2016-02-16" @default.
- W2272060897 modified "2023-10-17" @default.
- W2272060897 title "Intracellular and extracellular microtubule associated protein tau as a therapeutic target in Alzheimer disease and other tauopathies" @default.
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