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- W2272129809 abstract "目的：研究卵巢癌组织中端粒酶活性、粘附分子CD44 v5／v6的表达及其与卵巢癌恶性行为的关系。方法：TRAP—ELISA法半定量测定卵巢癌组织的端粒酶活性：FCM（Flow cytometru）技术分析DNA含量及粘附分子CD44 v5／v6的阳性表达率。结果：①端粒酶活性随着卵巢癌临床分期、病理分级的升高而显著增高（P〈0．05或0．01）．淋巴结转移及DNA异倍体组端粒酶活性显著高于无转移及DNA二倍体组（P〈0．05或0．01）；②随着临床分期、病理分级的升高，粘附分子CD44 v5／v6阳性表达率显著增加（P〈0．01或0．05）；淋巴结转移及DNA异倍体组CD44 v5／v6阳性表达率明显高于无转移组及DNA二倍体组（P〈0．01）；③随着端粒酶活性增加，CD44 v5／v6阳性表达率明显增高（P〈0．01）。结论：肿瘤细胞增殖活性相关的端粒酶活性和肿瘤转移相关的CD44 v5、v6都与卵巢癌的恶性程度及转移潜能密切相关，且二者之间存在相关性联合检测可从不同的角度评价卵巢癌的恶性行为。" @default.
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- W2272129809 date "2006-01-01" @default.
- W2272129809 modified "2023-09-23" @default.
- W2272129809 title "端粒酶活性及粘附分子CD44 v5／v6与卵巢癌恶性行为的相关性研究" @default.
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