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- W2272205207 abstract "BACKGROUND: Dialysis patients frequently receive intravenous iron supply. This study examines the effect of iron status on white blood cell (WBC) count, platelet count, and liver function. METHODS: We enrolled 41 patients (M/F: 24/17) with peritoneal dialysis, but without acute infection, liver cirrhosis. There were 8 patients with chronic hepatitis B or C. Body mass index (BMI) was checked. Laboratory data of WBC, platelet, albumin, liver enzyme (serum aspartate aminotransferase (SAST) and serum alanine aminotransferase (SALT)), serum ferritin and percentage of transferrin occupied by iron (transferrin saturation, TSAT) were obtained. Patients were subdivided into groups according to serum ferritin and TSAT levels: (1) ferritin ＜ 500 ng/mL (21 patients) and ferritin ≥ 500 ng/mL (20 patients), or (2) TSAT ＜ 20% (10 patients) and TSAT ≥ 20% (31 patients). RESULTS: BMI and chronic hepatitis (B or C) were not associated with abnormal liver function (SAST and SALT) in this study. There were no differences in WBC count, platelet count and albumin level between ferritin ＜ 500 ng/mL and ferritin ≥ 500 ng/ml groups, or between TSAT ＜ 20% and TSAT ≥ 20% groups. There was significant difference in SALT level between ferritin ＜ 500 ng/mL and ferritin ≥ 500 ng/mL (ferritin ＜ 500 ng/mL: 22.52 ± 2.34, ferritin ≥ 500 ng/mL: 29.65 ± 2.07, P = 0.028) groups. There were also significant differences in SAST and SALT levels between TSAT ＜ 20% and TSAT ≥ 20% groups (SAST: TSAT ＜ 20%: 21.30 ± 1.47, TSAT ≥ 20%: 29.58 ± 2.10, P = 0.036; SALT: TSAT ＜ 20%: 19.80 ± 1.87, TSAT ≥ 20%: 28.00 ± 1.97, P = 0.030). SALT value was significantly correlated positively with TSAT value (r = 0.412, P ＜ 0.05). CONCLUSION: There were no significant difference in WBC and platelet counts between patients with high (ferritin ≥ 500 ng/mL or TSAT ≥ 20%) and low (ferritin ＜ 500 ng/mL or TSAT ＜ 20%) iron status. High iron status was associated with increased liver enzymes." @default.
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- W2272205207 date "2013-06-01" @default.
- W2272205207 modified "2023-09-27" @default.
- W2272205207 title "Association of Serum Iron Markers to Hepatic Enzymes in Peritoneal Dialysis Patients" @default.
- W2272205207 doi "https://doi.org/10.6221/an.2012025" @default.
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