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- W2272206064 endingPage "937" @default.
- W2272206064 startingPage "923" @default.
- W2272206064 abstract "A major goal of current research in schizophrenia is to understand the biology underlying onset and early progression and to develop interventions that modify these processes. Biomarkers can play a critical role in identifying disease state, factors contributing to underlying progression, as well as predicting and monitoring response to treatment. Once biomarker-based therapeutics are established, biomarkers can guide treatment selection. It is increasingly clear that a wide range of potential biomarkers should be examined in schizophrenia, given the large number of genetic and environmental factors that have been identified as risk factors. New models for analysis of biomarkers are needed that represent the central nervous system as a highly complex, dynamic, and interactive system. Many tools are available with which to study relevant brain chemistry, but most are indirect measures and represent only a small fraction of the potential etiologic factors contributing to the molecular, structural and functional components of schizophrenia. This review represents the work of the International Society for CNS Clinical Trials and Methodology (ISCTM) Biomarkers Working Group. It discusses advantages and disadvantages of different categories of biomarkers and provides a summary of evidence that biomarkers representing inflammation, oxidative stress, endocannabinoids, glucocorticoid, and biogenic amines systems are dysregulated and potentially interactive in early phase schizophrenia. As has been recently demonstrated in several neurodevelopmental and neurodegenerative disorders, a multi-modal, longitudinal strategy involving a diverse array of biomarkers and new approaches to statistical modeling are needed to improve early interventions based on the fuller understanding." @default.
- W2272206064 created "2016-06-24" @default.
- W2272206064 creator A5050834331 @default.
- W2272206064 creator A5058044307 @default.
- W2272206064 creator A5059530469 @default.
- W2272206064 creator A5066465250 @default.
- W2272206064 creator A5070720166 @default.
- W2272206064 creator A5081001975 @default.
- W2272206064 date "2016-06-01" @default.
- W2272206064 modified "2023-09-23" @default.
- W2272206064 title "Biomarkers for drug development in early psychosis: Current issues and promising directions" @default.
- W2272206064 cites W1618446618 @default.
- W2272206064 cites W1964447157 @default.
- W2272206064 cites W1964544578 @default.
- W2272206064 cites W1965196441 @default.
- W2272206064 cites W1965724486 @default.
- W2272206064 cites W1970183794 @default.
- W2272206064 cites W1971221903 @default.
- W2272206064 cites W1973613551 @default.
- W2272206064 cites W1975346945 @default.
- W2272206064 cites W1975668251 @default.
- W2272206064 cites W1975952150 @default.
- W2272206064 cites W1978238793 @default.
- W2272206064 cites W1981885339 @default.
- W2272206064 cites W1983189779 @default.
- W2272206064 cites W1995096079 @default.
- W2272206064 cites W1996153970 @default.
- W2272206064 cites W2004539531 @default.
- W2272206064 cites W2004541878 @default.
- W2272206064 cites W2007044705 @default.
- W2272206064 cites W2007589469 @default.
- W2272206064 cites W2010425739 @default.
- W2272206064 cites W2012305372 @default.
- W2272206064 cites W2013551728 @default.
- W2272206064 cites W2014296883 @default.
- W2272206064 cites W2016441589 @default.
- W2272206064 cites W2017076975 @default.
- W2272206064 cites W2017802689 @default.
- W2272206064 cites W2019009474 @default.
- W2272206064 cites W2019393387 @default.
- W2272206064 cites W2020651859 @default.
- W2272206064 cites W2021016366 @default.
- W2272206064 cites W2021695398 @default.
- W2272206064 cites W2021813448 @default.
- W2272206064 cites W2021908480 @default.
- W2272206064 cites W2022767039 @default.
- W2272206064 cites W2022809683 @default.
- W2272206064 cites W2025921501 @default.
- W2272206064 cites W2031683990 @default.
- W2272206064 cites W2032220418 @default.
- W2272206064 cites W2032537064 @default.
- W2272206064 cites W2035368278 @default.
- W2272206064 cites W2036380865 @default.
- W2272206064 cites W2037249499 @default.
- W2272206064 cites W2041093488 @default.
- W2272206064 cites W2042643928 @default.
- W2272206064 cites W2042755650 @default.
- W2272206064 cites W2043676311 @default.
- W2272206064 cites W2043865307 @default.
- W2272206064 cites W2044284434 @default.
- W2272206064 cites W2044492513 @default.
- W2272206064 cites W2045347306 @default.
- W2272206064 cites W2050603486 @default.
- W2272206064 cites W2052297858 @default.
- W2272206064 cites W2052794650 @default.
- W2272206064 cites W2056547365 @default.
- W2272206064 cites W2056760696 @default.
- W2272206064 cites W2058860479 @default.
- W2272206064 cites W2060050678 @default.
- W2272206064 cites W2060801754 @default.
- W2272206064 cites W2060969944 @default.
- W2272206064 cites W2067270270 @default.
- W2272206064 cites W2070005343 @default.
- W2272206064 cites W2070331662 @default.
- W2272206064 cites W2071528273 @default.
- W2272206064 cites W2072102207 @default.
- W2272206064 cites W2073765419 @default.
- W2272206064 cites W2074170863 @default.
- W2272206064 cites W2074678903 @default.
- W2272206064 cites W2076390495 @default.
- W2272206064 cites W2079580613 @default.
- W2272206064 cites W2084285609 @default.
- W2272206064 cites W2086232796 @default.
- W2272206064 cites W2089067846 @default.
- W2272206064 cites W2090271911 @default.
- W2272206064 cites W2091571600 @default.
- W2272206064 cites W2092639477 @default.
- W2272206064 cites W2093248761 @default.
- W2272206064 cites W2094005621 @default.
- W2272206064 cites W2099589690 @default.
- W2272206064 cites W2099678317 @default.
- W2272206064 cites W2102486166 @default.
- W2272206064 cites W2102633604 @default.
- W2272206064 cites W2102874112 @default.
- W2272206064 cites W2104000439 @default.
- W2272206064 cites W2105071566 @default.
- W2272206064 cites W2106887445 @default.
- W2272206064 cites W2107282052 @default.