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- W2272430157 abstract "Purpose of review About one out of 10 patients with idiopathic pulmonary fibrosis (IPF) develop lung cancer. This review provides an epidemiology and clinical update of the association of these two lethal diseases. In addition, we focus on the emerging overlapping epigenetic mechanisms in both diseases. Recent findings In a vast majority of cases, lung cancer is diagnosed during the clinical and radiological follow-up for the fibrosis. The risk of development of lung cancer in IPF is higher for older male smokers and there is a significantly higher prevalence of lung cancer in the combined IPF and emphysema syndrome compared with fibrosis only. The association of two lethal diseases, such as IPF and lung cancer, carries a very poor outcome and the correct treatment strategy, particularly for advanced forms of lung cancer, is still unclear. Summary The two novel drugs approved for IPF, pirfenidone and nintedanib, open a new scenario in which treated patients with fibrosis will live longer, and possibly have a lower incidence of lung cancer. However, prospective studies are urgently needed to definitively clarify the role of lung cancer treatment in the management of IPF patients. Furthermore, common epigenetic alterations may represent a promising target for therapeutic approaches in the near future." @default.
- W2272430157 created "2016-06-24" @default.
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- W2272430157 creator A5012539336 @default.
- W2272430157 creator A5030610987 @default.
- W2272430157 creator A5062188933 @default.
- W2272430157 date "2015-11-01" @default.
- W2272430157 modified "2023-10-18" @default.
- W2272430157 title "Idiopathic pulmonary fibrosis and lung cancer" @default.
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- W2272430157 doi "https://doi.org/10.1097/mcp.0000000000000217" @default.
- W2272430157 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26390339" @default.
- W2272430157 hasPublicationYear "2015" @default.
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