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- W2272430508 abstract "Objective Parents and health professionals believe that recurrent respiratory tract infections (RRTI) have a large impact on children with Down syndrome (DS). We studied the relation between parent-reported RRTI and development, behaviour and health-related quality of life (HRQoL) in 8-year-old children with DS. Method During a 3-year period, 325 children with DS were recruited for inclusion in this observational study. Parents were asked to fill in the Child Behavior Checklist and TNO-AZL Children's Quality of Life Parent Form. A psychological assistant administrated the McCarthy Scales of Children's Abilities. The children were divided into a group with presence of RRTI (RRTI +) and a group without RRTI (RRTI −), on the basis of parental report. Linear regression analyses were performed to assess the effect of RRTI, while correcting for the influence of confounders. Results Compared with RRTI − children (n = 176), RRTI + children (n = 149, 46%) showed decreased mental and motor development (mean developmental age 3.67 vs. 4.08 years), more behavioural problems and lower scores on most HRQoL scales (P < 0.05). Moreover, school enrolment is less favourable in RRTI + children. Conclusion In 8-year-olds with DS, the children with parent-reported RRTI show more delayed development, more behavioural problems and lower HRQoL compared with the children without RRTI. Although this association does not prove a causal relationship, further studies should focus on this, because RRTI are potentially preventable." @default.
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- W2272430508 date "2012-07-01" @default.
- W2272430508 modified "2023-10-16" @default.
- W2272430508 title "Significant impact of recurrent respiratory tract infections in children with Down syndrome" @default.
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- W2272430508 doi "https://doi.org/10.1111/j.1365-2214.2012.01413.x" @default.
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