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- W2272476314 abstract "Frutalin is the alpha-D-galactose-binding Jacalin-related lectin from Artocarpus incisa seeds. This plant lectin was successfully used on the recognition of cancer metastasis, specifically those of breast and thyroid gland, due to its ability to interact with galactose complexes and thus potentially combine with cancer cells surfaces containing these sugars. It can be potentially used as a histochemical probe in the diagnostic of several cancers. However, Frutalin extraction from seeds is a long process with low yields and a mixture of many isolectins can be obtained. Frutalin is thought to be synthesized as a pre-pro-lectin, consisting of a signal sequence, a pro-peptide, a 20-amino-acid betachain, a 4-amino-acid linker peptide and a 133-amino-acid alpha-chain. In mature Frutalin, the signal sequence and the pro-peptide may be removed through post and/or co-translational processing and the linker excised to generate two chains, alpha and beta. Active Frutalin consists of a tetrameric protein and each one of its subunits is made of one alpha chain and one beta chain non-covalently linked." @default.
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- W2272476314 date "2007-06-01" @default.
- W2272476314 modified "2023-09-27" @default.
- W2272476314 title "Cloning and expression of frutalin, an alpha-dgalactose-binding plant lectin, in Pichia pastoris" @default.
- W2272476314 hasPublicationYear "2007" @default.
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