Matches in SemOpenAlex for { <https://semopenalex.org/work/W2272624151> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2272624151 endingPage "9" @default.
- W2272624151 startingPage "483" @default.
- W2272624151 abstract "The pharmacologic specificity of the sensitization to naltrexone induced by acute opioid pretreatment was studied in rats trained to lever-press on a multiple-trial, fixed-interval 3-min schedule of food reinforcement. Cumulative doses of naltrexone were given until responding was suppressed; control naltrexone ED50 values for decreasing response rates ranged from 5.0 to 22 mg/kg. Agonists were administered 4 hr before naltrexone challenge. Pretreatment with morphine (10 mg/kg) initially produced a 4-fold shift to the left of the naltrexone dose-effect curve, but after repeated weekly testing with various agonists, produced a 1700-fold shift. Pretreatment with other millimicrons agonists (i.e., 0.3 mg/kg of levorphanol, 0.06 mg/kg of fentanyl and 3.0 mg/kg of methadone) produced similarly large (100- to 250-fold) increases in sensitivity to the rate-decreasing effects of naltrexone. On the other hand, pretreatment with agonists selective for kappa (1.0 mg/kg of ethylketocyclazocine and 3.0 mg/kg of U-50,488) or sigma (10 mg/kg of [+]-N-allylnormetazocine) receptors, produced smaller (10-fold) changes in sensitization to naltrexone. Neither dextrorphan (3.0 mg/kg) nor pentobarbital (18 mg/kg) pretreatment altered sensitivity to naltrexone. Thus, the sensitization to naltrexone induced by acute opioid pretreatment was a stereoselective, opioid-specific effect, and appeared to be mediated primarily by a mu-opioid mechanism. With repeated testing, the effect of acute morphine pretreatment was comparable to that reported after chronic administration, thus supporting the hypothesis that this phenomenon reflects receptor-mediated changes that underlie the state of opioid physical dependence." @default.
- W2272624151 created "2016-06-24" @default.
- W2272624151 creator A5030762376 @default.
- W2272624151 creator A5058790605 @default.
- W2272624151 date "1990-05-01" @default.
- W2272624151 modified "2023-10-12" @default.
- W2272624151 title "Pharmacologic characterization of the sensitization to the rate-decreasing effects of naltrexone induced by acute opioid pretreatment in rats." @default.
- W2272624151 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2338644" @default.
- W2272624151 hasPublicationYear "1990" @default.
- W2272624151 type Work @default.
- W2272624151 sameAs 2272624151 @default.
- W2272624151 citedByCount "34" @default.
- W2272624151 countsByYear W22726241512013 @default.
- W2272624151 countsByYear W22726241512015 @default.
- W2272624151 countsByYear W22726241512022 @default.
- W2272624151 crossrefType "journal-article" @default.
- W2272624151 hasAuthorship W2272624151A5030762376 @default.
- W2272624151 hasAuthorship W2272624151A5058790605 @default.
- W2272624151 hasConcept C126322002 @default.
- W2272624151 hasConcept C170493617 @default.
- W2272624151 hasConcept C185592680 @default.
- W2272624151 hasConcept C203014093 @default.
- W2272624151 hasConcept C2776217527 @default.
- W2272624151 hasConcept C2777389121 @default.
- W2272624151 hasConcept C2777972943 @default.
- W2272624151 hasConcept C2778750930 @default.
- W2272624151 hasConcept C2779248205 @default.
- W2272624151 hasConcept C2779591118 @default.
- W2272624151 hasConcept C2781063702 @default.
- W2272624151 hasConcept C2781245242 @default.
- W2272624151 hasConcept C42219234 @default.
- W2272624151 hasConcept C71924100 @default.
- W2272624151 hasConcept C98274493 @default.
- W2272624151 hasConceptScore W2272624151C126322002 @default.
- W2272624151 hasConceptScore W2272624151C170493617 @default.
- W2272624151 hasConceptScore W2272624151C185592680 @default.
- W2272624151 hasConceptScore W2272624151C203014093 @default.
- W2272624151 hasConceptScore W2272624151C2776217527 @default.
- W2272624151 hasConceptScore W2272624151C2777389121 @default.
- W2272624151 hasConceptScore W2272624151C2777972943 @default.
- W2272624151 hasConceptScore W2272624151C2778750930 @default.
- W2272624151 hasConceptScore W2272624151C2779248205 @default.
- W2272624151 hasConceptScore W2272624151C2779591118 @default.
- W2272624151 hasConceptScore W2272624151C2781063702 @default.
- W2272624151 hasConceptScore W2272624151C2781245242 @default.
- W2272624151 hasConceptScore W2272624151C42219234 @default.
- W2272624151 hasConceptScore W2272624151C71924100 @default.
- W2272624151 hasConceptScore W2272624151C98274493 @default.
- W2272624151 hasIssue "2" @default.
- W2272624151 hasLocation W22726241511 @default.
- W2272624151 hasOpenAccess W2272624151 @default.
- W2272624151 hasPrimaryLocation W22726241511 @default.
- W2272624151 hasRelatedWork W1856798736 @default.
- W2272624151 hasRelatedWork W1898458505 @default.
- W2272624151 hasRelatedWork W1924136303 @default.
- W2272624151 hasRelatedWork W1971389354 @default.
- W2272624151 hasRelatedWork W1994940598 @default.
- W2272624151 hasRelatedWork W2008171438 @default.
- W2272624151 hasRelatedWork W2104920518 @default.
- W2272624151 hasRelatedWork W2153342137 @default.
- W2272624151 hasRelatedWork W2272624151 @default.
- W2272624151 hasRelatedWork W1971549975 @default.
- W2272624151 hasVolume "253" @default.
- W2272624151 isParatext "false" @default.
- W2272624151 isRetracted "false" @default.
- W2272624151 magId "2272624151" @default.
- W2272624151 workType "article" @default.