Matches in SemOpenAlex for { <https://semopenalex.org/work/W2272772407> ?p ?o ?g. }
- W2272772407 endingPage "595" @default.
- W2272772407 startingPage "589" @default.
- W2272772407 abstract "The treatment of intrahepatic cholestasis has been limited, and development of an effective drug is needed. Clinical studies have shown that Yinzhihuang (YZH), a traditional Chinese decoction, enhances bilirubin clearance. The goal of this study was to determine the protective effect of YZH on experimental intrahepatic cholestasis in young rats and to explore its underlying molecular mechanisms. Intrahepatic cholestasis in rats was induced by α-naphthylisothiocyanate (ANIT) on days 1 and 8. The rats received YZH, ursodeoxycholic acid (UDCA), or vehicle for 9 d and were killed on either day 3 or day 10. Serum biomarkers, liver histology, and the distribution of protein and mRNA expression of Mrp2 and Bsep were analyzed. YZH treatment resulted in decreased levels of serum biomarkers except γ-glutamyl transpeptidase, attenuated liver histological injuries, increased protein expressions of Mrp2 and Bsep, and upregulated expressions of Mrp2 and Bsep mRNAs. The effects of YZH on serum biomarkers (aminotransferase, alanine aminotransferase, and direct bilirubin), liver histology, and Mrp2 mRNA expressions were significantly greater and earlier than those of UDCA. Our results suggest that YZH has protective effect against ANIT-induced intrahepatic cholestasis in rats, through upregulation of Mrp2 and Bsep expressions." @default.
- W2272772407 created "2016-06-24" @default.
- W2272772407 creator A5000182174 @default.
- W2272772407 creator A5002382258 @default.
- W2272772407 creator A5029555464 @default.
- W2272772407 creator A5032576406 @default.
- W2272772407 creator A5039969636 @default.
- W2272772407 creator A5074257037 @default.
- W2272772407 creator A5079853810 @default.
- W2272772407 date "2015-12-08" @default.
- W2272772407 modified "2023-10-11" @default.
- W2272772407 title "Yinzhihuang attenuates ANIT-induced intrahepatic cholestasis in rats through upregulation of Mrp2 and Bsep expressions" @default.
- W2272772407 cites W1586410646 @default.
- W2272772407 cites W1592483428 @default.
- W2272772407 cites W1606649779 @default.
- W2272772407 cites W1689859172 @default.
- W2272772407 cites W1966314388 @default.
- W2272772407 cites W1966916675 @default.
- W2272772407 cites W1980089776 @default.
- W2272772407 cites W1987211528 @default.
- W2272772407 cites W1994271325 @default.
- W2272772407 cites W1994912901 @default.
- W2272772407 cites W1995182877 @default.
- W2272772407 cites W2003680983 @default.
- W2272772407 cites W2006881928 @default.
- W2272772407 cites W2009145049 @default.
- W2272772407 cites W2016714682 @default.
- W2272772407 cites W2017805648 @default.
- W2272772407 cites W2018981240 @default.
- W2272772407 cites W2029542850 @default.
- W2272772407 cites W2036798783 @default.
- W2272772407 cites W2045759446 @default.
- W2272772407 cites W2070459544 @default.
- W2272772407 cites W2079498725 @default.
- W2272772407 cites W2082882207 @default.
- W2272772407 cites W2083713791 @default.
- W2272772407 cites W2095481879 @default.
- W2272772407 cites W2100051004 @default.
- W2272772407 cites W2103094637 @default.
- W2272772407 cites W2113427887 @default.
- W2272772407 cites W2113493709 @default.
- W2272772407 cites W2133074258 @default.
- W2272772407 cites W2154576630 @default.
- W2272772407 cites W2156492879 @default.
- W2272772407 cites W2157050265 @default.
- W2272772407 cites W2160429467 @default.
- W2272772407 cites W2160960781 @default.
- W2272772407 cites W2186577008 @default.
- W2272772407 cites W2409057916 @default.
- W2272772407 cites W2413416830 @default.
- W2272772407 cites W2417036406 @default.
- W2272772407 cites W4241721928 @default.
- W2272772407 cites W4293201222 @default.
- W2272772407 cites W4299524581 @default.
- W2272772407 doi "https://doi.org/10.1038/pr.2015.252" @default.
- W2272772407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26646631" @default.
- W2272772407 hasPublicationYear "2015" @default.
- W2272772407 type Work @default.
- W2272772407 sameAs 2272772407 @default.
- W2272772407 citedByCount "16" @default.
- W2272772407 countsByYear W22727724072016 @default.
- W2272772407 countsByYear W22727724072017 @default.
- W2272772407 countsByYear W22727724072018 @default.
- W2272772407 countsByYear W22727724072019 @default.
- W2272772407 countsByYear W22727724072020 @default.
- W2272772407 countsByYear W22727724072021 @default.
- W2272772407 countsByYear W22727724072022 @default.
- W2272772407 countsByYear W22727724072023 @default.
- W2272772407 crossrefType "journal-article" @default.
- W2272772407 hasAuthorship W2272772407A5000182174 @default.
- W2272772407 hasAuthorship W2272772407A5002382258 @default.
- W2272772407 hasAuthorship W2272772407A5029555464 @default.
- W2272772407 hasAuthorship W2272772407A5032576406 @default.
- W2272772407 hasAuthorship W2272772407A5039969636 @default.
- W2272772407 hasAuthorship W2272772407A5074257037 @default.
- W2272772407 hasAuthorship W2272772407A5079853810 @default.
- W2272772407 hasBestOaLocation W22727724071 @default.
- W2272772407 hasConcept C104317684 @default.
- W2272772407 hasConcept C126322002 @default.
- W2272772407 hasConcept C127561419 @default.
- W2272772407 hasConcept C134018914 @default.
- W2272772407 hasConcept C149011108 @default.
- W2272772407 hasConcept C185592680 @default.
- W2272772407 hasConcept C2776637226 @default.
- W2272772407 hasConcept C2777513400 @default.
- W2272772407 hasConcept C2778593092 @default.
- W2272772407 hasConcept C2780965833 @default.
- W2272772407 hasConcept C2910800957 @default.
- W2272772407 hasConcept C36201501 @default.
- W2272772407 hasConcept C44312359 @default.
- W2272772407 hasConcept C55493867 @default.
- W2272772407 hasConcept C71924100 @default.
- W2272772407 hasConceptScore W2272772407C104317684 @default.
- W2272772407 hasConceptScore W2272772407C126322002 @default.
- W2272772407 hasConceptScore W2272772407C127561419 @default.
- W2272772407 hasConceptScore W2272772407C134018914 @default.
- W2272772407 hasConceptScore W2272772407C149011108 @default.
- W2272772407 hasConceptScore W2272772407C185592680 @default.