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- W2272905511 abstract "C—erbB-2为人类原癌基因,也称HER-2/neu,位于第17对染色体长臂21位(17q21),编码1255个具有跨膜酪氨酸激酶活性的生长因子受体,是表皮生长因子受体家族成员之一,分子量约为185kD,因此又被称为p185。C—erbB-2在正常组织中不表达或微量表达,人类肿瘤组织如乳腺癌、卵巢癌、子宫内膜癌、输卵管癌、宫颈癌、前列腺癌、胃癌、唾液腺癌、舌癌、头颈部鳞癌、非小细胞性肺癌,C—erbB-2过度表达的约30%。临床评估C—erbB一2表达状态,主要通过免疫组化法(IHC)和原位荧光原位杂交法(FISH),IHC检测为C—erbB-2(+++)或IHC检测为C—erbB-2(++)/FISH检测为(+)者,确定为C—erbB-2过度表达。C—erbB一2是乳腺癌重要的分子生物学标记,其表达过度与否不仅在乳腺癌发生、发展、转移和预后中起重要作用,对乳腺癌的化疗也具有十分重要的临床参考价值。" @default.
- W2272905511 created "2016-06-24" @default.
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- W2272905511 creator A5083977430 @default.
- W2272905511 date "2006-12-25" @default.
- W2272905511 modified "2023-09-25" @default.
- W2272905511 title "C-erbB-2过度表达对乳腺癌术后化疗选择的影响" @default.
- W2272905511 hasPublicationYear "2006" @default.
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