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• W2272935647 abstract "22025 Background: Id1, involved in cell differentiation and tumor angiogenesis, has recently showed to mediate lung MTS from breast cancer. While the importance of Id1 in CaP endothelial cells is well established, its expression (exp.) and role in CaP cells is controversial. Using a new MoAb (195–14) for immunohistochemistry (IHC), Id1 exp. is limited to some PP breast tumors and other non-adenocarcinoma tumor types. A CaP mouse model shows higher Id1 exp. in poorly differentiated tumors. A previous study showed 3% of Id1-expressing CaP in unselected patients (pts). Whether Id1 exp. is a relevant feature in PP CaP tumor cells is still unknown. Therefore, we tested 195–14 in primary high-risk, HR, metastatic CaP samples and matched MTS. Methods: Thirty-three pts were selected. Formalin-fixed and paraffin- embedded prostate biopsy samples of each patient and matched MTS samples of 16 of them were stained and scored for tumor and endothelial cell Id1 exp. Anti-human Id1 rabbit MoAb 195–14 (diluted 1:500), (Biocheck), was used for IHC. Results: Most pts (median age 70) had high-risk (70% T3-T4; 61% Gleason 8 to 10; mean PSA at onset 58 ng/ml), HR, metastatic CaP (79% had 2 or more MTS locations including lymph node, bone or visceral MTS). 94% previously progressed to docetaxel. Median time-to-progression after chemotherapy initiation was 18 weeks and median overall survival 7 months, reflecting PP. Interestingly, 39% of primary CaP and 38% of MTS showed Id1 tumor cell exp. This unexpected higher incidence of Id1 exp. may be due to the selection of high-risk, PP, treatment-refractory pts. Consistently with other reports, 79% of primary neoplasms and 81% of MTS showed endothelial Id1 exp. Size of samples may account for Id1 exp. underestimation. Conclusions: Consistently with preclinical data, in this PP CaP cohort, Id1 exp. seems to be significantly higher than reported in unselected pts. For the first time, using a MoAb against Id1, CaP MTS demonstrate Id1 exp. with similar exp. patterns than primary tumors. Whether Id1 exp. profile is in fact crucial for PP and metastatic initiation of high-risk CaP needs further research. No significant financial relationships to disclose." @default.
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• W2272935647 date "2008-05-20" @default.
• W2272935647 modified "2023-10-18" @default.
• W2272935647 title "Inhibitor of differentiation-1 (Id1) characterization in poor prognosis (PP) hormone-refractory (HR) metastatic prostate cancer (CaP) primary tumors and matched metastases (MTS) using a new monoclonal antibody (MoAb)" @default.
• W2272935647 doi "https://doi.org/10.1200/jco.2008.26.15_suppl.22025" @default.
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